ADRB1
From SNPedia
| is a | gene |
| is | mentioned by |
| Full name | adrenergic, beta-1-, receptor |
| EntrezGene | 153 |
| PheGenI | 153 |
| VariationViewer | 153 |
| ClinVar | ADRB1 |
| GeneCards | ADRB1 |
| dbSNP | 153 |
| Diseases | ADRB1 |
| SADR | 153 |
| HugeNav | 153 |
| wikipedia | ADRB1 |
| ADRB1 | |
| gopubmed | ADRB1 |
| EVS | ADRB1 |
| HEFalMp | ADRB1 |
| MyGene2 | ADRB1 |
| 23andMe | ADRB1 |
| UniProt | P08588 |
| Ensembl | ENSG00000043591 |
| OMIM | 109630 |
| # SNPs | 2 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| rs1801252 | 3 | 114,044,277 | |
| rs1801253 | 1.1 | 114,045,297 |
Polymorphisms in the beta-1 adrenergic receptor gene ADRB1 may explain up to 20% of the variability in how individuals respond to treatment with beta blocker drugs used to help lower blood pressure. It may also affect lipid metabolism.
Associated SNPs in the gene include:
rs1801253 may be a susceptibility polymorphism for lipid metabolism disruption. [PMID 24972470]
Dionne et al. (2002) found that the arg389 allele was associated with greater body weight with each arg389 allele being associated with a 2.91 kg greater weight.
