Have questions? Visit https://www.reddit.com/r/SNPedia

APP

From SNPedia

is agene
is mentioned by
Full nameamyloid beta (A4) precursor protein
EntrezGene351
PheGenI351
VariationViewer351
ClinVarAPP
GeneCardsAPP
dbSNP351
DiseasesAPP
SADR351
HugeNav351
wikipediaAmyloid_precursor_protein
googleAPP
gopubmedAPP
EVSAPP
HEFalMpAPP
MyGene2APP
23andMeAPP
UniProtP05067
EnsemblENSG00000142192
OMIM104760
# SNPs28
 Max MagnitudeChromosome positionSummary
i5004476
rs145564988625,891,785
rs193922916525,897,619
rs21448425,881,968
rs281865161025,897,626
rs36404826,171,723
rs46643326,171,645
rs46644826,171,790
rs53287683225,881,337
rs63749810025,891,853
rs63749964025,891,783
rs63750064625,897,605
rs63750066025,891,796
rs63750151725,891,761
rs63750264025,891,784
rs63750363025,897,642
rs63750399625,891,787
rs63750579025,891,856
rs63750643625,891,793
rs63750671625,891,858
rs63750734725,891,790
rs63750847425,897,620Alzheimer's related, 1% geno is good
rs63750851725,891,786
rs63750868725,891,789
rs63750921625,891,820
rs63750973825,891,792
rs63751039725,891,855
rs63751122725,891,765

The APP gene encodes amyloid precursor protein, an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. Its primary function is not known, though it has been implicated as a regulator of synapse formation, neural plasticity and iron export. APP is best known as the precursor molecule whose proteolysis generates beta amyloid (Aβ), a polypeptide containing 37 to 49 amino acid residues, whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients.Wikipedia

Around 20 mutations in the APP gene are thought to be associated with either Alzheimer's disease or Cerebral amyloid angiopathy.