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BAIAP2

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# SNPs8
 Max MagnitudeChromosome positionSummary
rs393449281,060,164
rs496923981,036,744
rs496938581,095,090
rs721043881,086,380
rs806723581,050,837
rs807962681,053,072
rs807978181,076,348
rs990164881,061,908

The BAIAP2 gene on chromosome 17 encodes the insulin receptor tyrosine kinase substrate protein of 53 kDa (IRSp53).

A 2016 review and meta-analysis of genetic, pharmacogenetic and biochemical studies on ADHD in adults concluded that an association was seen for the BAIAP2 gene, but no other genetic, pharmacogenetic or biochemical association was found to be significantly associated. The association between adult ADHD and several variants in the BAIAP2 gene was not observed in children.[PMID 27217152OA-icon.png]

The variants reported as being statistically significant were:

  • rs8079781; carriers of a T allele have slightly lower (0.8-0.87x) risk for adult ADHD
  • rs8079626-rs7210438, GC haplotype has slightly lower (0.8x), AC haplotype has slightly higher (1.2x), risk for adult ADHD