FKBP5
From SNPedia
| is a | gene |
| is | mentioned by |
| Full name | FK506 binding protein 5 |
| EntrezGene | 2289 |
| PheGenI | 2289 |
| VariationViewer | 2289 |
| ClinVar | FKBP5 |
| GeneCards | FKBP5 |
| dbSNP | 2289 |
| Diseases | FKBP5 |
| SADR | 2289 |
| HugeNav | 2289 |
| wikipedia | FKBP5 |
| FKBP5 | |
| gopubmed | FKBP5 |
| EVS | FKBP5 |
| HEFalMp | FKBP5 |
| MyGene2 | FKBP5 |
| 23andMe | FKBP5 |
| UniProt | Q13451 |
| Ensembl | ENSG00000096060 |
| OMIM | 602623 |
| # SNPs | 12 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| rs1360780 | 2.1 | 35,639,794 | |
| rs3777747 | 0 | 35,611,225 | |
| rs3800373 | 0 | 35,574,699 | |
| rs4713902 | 0 | 35,646,249 | |
| rs4713916 | 0 | 35,702,206 | |
| rs737054 | 0 | 35,607,710 | |
| rs755658 | 0 | 35,581,893 | |
| rs7748266 | 0 | 35,624,967 | |
| rs7757037 | 0 | 35,580,459 | |
| rs9296158 | 0 | 35,599,305 | |
| rs9394309 | 0 | 35,654,004 | |
| rs9470080 | 0 | 35,678,658 |
The FKBP5 gene appears to influence glucocorticoid function, mediated by a complex formed with the glucocorticoid receptor.
SNPs in the FKBP5 gene have been associated with several psychiatric disorders:
- Response to antidepressants has been seen for:
- rs4713916, in the promoter region
- rs1360780, in intron 2, which also is correlated with overall depression risk
- rs3800373, in the 3' untranslated region
- An association with bipolar disorder has been reported for:
