Have questions? Visit https://www.reddit.com/r/SNPedia

Gs306

From SNPedia

Gs306
Magnitude 6.5
Repute Bad
Summary Poor metabolizer of fluoropyrimidines (e.g. 5-fluorouracil, capecitabine or tegafur).
Criteria Gs306/criteria


This genoset predicts the presence of two DPYD gene mutations associated with nonfunctional alleles, and therefore greatly increased toxicity if administered chemotherapeutic fluoropyridimines such as 5-fluorouracil and capecitabine. Patients with this genoset are at high risk according to the FDA of toxic (even lethal) reactions and should avoid these drugs.