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Gs312

From SNPedia

Gs312
Magnitude 5.5
Repute Bad
Summary Intermediate metabolizer of fluoropyrimidines (such as 5-fluorouracil and capecitabine).
Criteria Gs312/criteria


This genoset predicts the presence of one nonfunctional DPYD allele, and therefore possible toxicity risk if administered chemotherapeutic fluoropyrimidines such as 5-fluorouracil, capecitabine or tegafur. CPIC and the FDA recommend either pharmacokinetic testing and/or reduced (50%) initial dosing of such drugs in patients with one nonfunctional DPYD allele.