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PTEN

From SNPedia

is agene
is mentioned by
Full namephosphatase and tensin homolog
EntrezGene5728
PheGenI5728
VariationViewer5728
ClinVarPTEN
GeneCardsPTEN
dbSNP5728
DiseasesPTEN
SADR5728
HugeNav5728
wikipediaPTEN
googlePTEN
gopubmedPTEN
EVSPTEN
HEFalMpPTEN
MyGene2PTEN
23andMePTEN
UniProtP60484
EnsemblENSG00000171862
OMIM601728
# SNPs248
 Max MagnitudeChromosome positionSummary
i5000260
i5000261
i5000262
i5000263
i5000264
i5000265
i5000267
i5000270
i5000273
i5000274
i5000275
i5000276
i5000277
i5000279
i5000280
i5000281
i5000282
i5000285
i5000286
i6017159
i6017162
i6017178
i6017183
i6017188
i6017195
i6017196
i6017210
i6017211
i6017218
i6017222
i6017224
i6017226
i6017232
rs104894184087,952,159
rs1049092087,925,886
rs10575178096.387,965,286
rs10575202086.387,933,012
rs10575206226.387,933,189
rs10575209006.387,957,893
rs10575210606.387,894,110
rs10575248746.387,864,514
rs1219092186.387,933,145
rs1219092196.387,957,915
rs1219092206.387,933,228
rs1219092216.387,952,135
rs1219092226.387,933,127
rs1219092236.387,933,129
rs1219092246.387,933,147
rs1219092256.387,894,049
rs1219092266.387,925,557
... further results

Along with the Androgen Receptor (AR), increasing expression of this gene increases the risk of breast cancer while reducing the risk of prostate cancer and vice versa. 10.1038/onc.2011.144

The New York Times reports that mutations in the PTEN gene may cause both tuberous sclerosis and autism. Clinical trials are under way to determine whether the same drugs can be used to treat both conditions.

10.1056/NEJMoa1113966 NEJM PTEN Mutations as a Cause of Constitutive Insulin Sensitivity and Obesity