Have questions? Visit https://www.reddit.com/r/SNPedia

Pharmacogenomics

From SNPedia

[PMID 28629370] Pharmacogenetic testing through the direct-to-consumer genetic testing company 23andMe.


Drugs Gene Variant SNP Purpose of test FDA/PharmGKB Guidance Guidelines
Abacavir HLA-B *57:01 rs2395029 Hypersensitivity reactions Genetic testing required CPIC, DPWG CPIC, DPWG
Acetaldehyde ALDH2 *2 rs671 Toxicity and risk of oesophageal squamous cell carcinoma No recommendation
Clopidogrel (Plavix®) CYP2C19 *2 rs4244285 Efficacy and ADRs Genetic testing recommendation CPIC, DPWG
*3 rs4986893
*4 rs28399504
*8 rs41291556
*17 rs12248560
Fluorouracil (Adrucil®) DPYD *2A rs3918290 Toxicity and ADRs Actionable PGx CPIC, DPWG
Peginterferon alpha (PEG-IFN-alpha) & ribavirin (RBV) 19q13 region rs8099917 Hepatitis C treatment failure Actionable PGx CPIC
Phenytoin CYP2C9 *2 rs1799853 Sensitivity and Dosage adjustment Actionable PGx CPIC, DPWG
*3 rs1057910
Proton Pump Inhibitor (PPI) CYP2C19 *2 rs4244285 Efficacy and Dosage adjustment Informative PGx DPWG
*3 rs4986893
*4 rs28399504
*8 rs41291556
*17 rs12248560
Pseudocholinesterase BCHE F1 rs28933389 ADR - extended paralysis and apnoea Actionable PGx
Deficiency F2 rs28933390
A rs1799807
Simvastatin SLCO1B1 *5 rs4149056 ADR - Myopathy No recommendation CPIC
Sulfonylurea CYP2C9 *2 rs1799853 Efficacy and Dosage adjustment No recommendation DPWG
*3 rs1057910
Thiopurine Methyltransferase TPMT c.460G > A, *3B rs1800460 Toxicity and ADRs Genetic testing recommended CPIC, DPWG
c.238G > C, *2 rs1800462
c.719A > G, *3C rs1142345
Warfarin CYP2C9 *2 rs1799853 Efficacy and Dosage adjustment Actionable PGx CPIC
*3 rs1057910