rs10010131
| Orientation | plus |
| Stabilized | plus |
| Make rs10010131(A;A) |
| Make rs10010131(A;G) |
| Make rs10010131(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 4 |
| Position | 6291188 |
| Gene | WFS1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs10010131 |
| dbSNP (classic) | rs10010131 |
| ClinGen | rs10010131 |
| ebi | rs10010131 |
| HLI | rs10010131 |
| Exac | rs10010131 |
| Gnomad | rs10010131 |
| Varsome | rs10010131 |
| LitVar | rs10010131 |
| Map | rs10010131 |
| PheGenI | rs10010131 |
| Biobank | rs10010131 |
| 1000 genomes | rs10010131 |
| hgdp | rs10010131 |
| ensembl | rs10010131 |
| geneview | rs10010131 |
| scholar | rs10010131 |
| rs10010131 | |
| pharmgkb | rs10010131 |
| gwascentral | rs10010131 |
| openSNP | rs10010131 |
| 23andMe | rs10010131 |
| SNPshot | rs10010131 |
| SNPdbe | rs10010131 |
| MSV3d | rs10010131 |
| GWAS Ctlg | rs10010131 |
| GMAF | 0.2677 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
[PMID 20028947
] Detailed investigation of the role of common and low frequency WFS1 variants in type 2 diabetes risk
[PMID 20361036] Gene-gene interactions lead to higher risk for development of type 2 diabetes in an ashkenazi jewish population
[PMID 20802253] Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion
[PMID 22513821] The association of genetic variants of type 2 diabetes with kidney function
[PMID 18040659] Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations.
[PMID 18060660] Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program.
[PMID 18426861] Association analysis of type 2 diabetes Loci in type 1 diabetes.
[PMID 18591388] Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.
[PMID 18694974] Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study.
[PMID 18782870] Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008.
[PMID 18984664] Common type 2 diabetes risk gene variants associate with gestational diabetes.
[PMID 19056611] Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
[PMID 19096518] Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.
[PMID 19207020] Meta-analysis in genome-wide association studies.
[PMID 19279076] Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men.
[PMID 19324937] Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults.
[PMID 19330314] A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion.
[PMID 19341491] Genome-based prediction of common diseases: methodological considerations for future research.
[PMID 19455305] No association of multiple type 2 diabetes loci with type 1 diabetes.
[PMID 19460916] Genetic architecture of type 2 diabetes: recent progress and clinical implications.
[PMID 19502414] Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.
[PMID 19526209] Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?
[PMID 19602701] Underlying genetic models of inheritance in established type 2 diabetes associations.
[PMID 19862325] PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.
[PMID 20017978] Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study.
[PMID 20018041] The effect of multiple genetic variants in predicting the risk of type 2 diabetes.
[PMID 20043853] Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.
[PMID 20144327] A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel.
[PMID 20509872] Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.
[PMID 20712903] Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
[PMID 21127832] Decreased insulin secretion and increased risk of type 2 diabetes associated with allelic variations of the WFS1 gene: the Data from Epidemiological Study on the Insulin Resistance Syndrome (DESIR) prospective study.
[PMID 21278902] Genetic risk profiling for prediction of type 2 diabetes.
[PMID 22461567] Diabetes-associated common genetic variation and its association with GLP-1 concentrations and response to exogenous GLP-1.
[PMID 23257691] Association of rs734312 and rs10010131 polymorphisms in WFS1 gene with type 2 diabetes mellitus: a meta-analysis
[PMID 22996131] Monogenic models: what have the single gene disorders taught us?
[PMID 23298195] Association study of genetic variants of 17 diabetes-related genes/loci and cardiovascular risk and diabetic nephropathy in the Chinese She population.
| ClinVar | |
|---|---|
| Risk | rs10010131(G;G) |
| Alt | rs10010131(G;G) |
| Reference | rs10010131(A;A) |
| Significance | Other |
| Disease | Diabetes mellitus not specified WFS1-Related Spectrum Disorders Nonsyndromic Hearing Loss |
| Variation | info |
| Gene | WFS1 |
| CLNDBN | Diabetes mellitus, noninsulin-dependent, association with not specified WFS1-Related Spectrum Disorders Nonsyndromic Hearing Loss, Dominant |
| Reversed | 0 |
| HGVS | NC_000004.11:g.6292915A>G |
| CLNSRC | OMIM Allelic Variant |
| CLNACC | RCV000004785.4, RCV000038664.7, RCV000273205.1, RCV000325882.1, |
[PMID 30846969] Gene x Gene Interactions Highlight the Role of Incretin Resistance for Insulin Secretion.
