Have questions? Visit https://www.reddit.com/r/SNPedia

rs10748842

From SNPedia

Orientationplus
Stabilizedplus
Make rs10748842(C;C)
Make rs10748842(C;T)
Make rs10748842(T;T)
ReferenceGRCh38 38.1/142
Chromosome10
Position81889983
GeneNRG3
is asnp
is mentioned by
dbSNPrs10748842
dbSNP (classic)rs10748842
ClinGenrs10748842
ebirs10748842
HLIrs10748842
Exacrs10748842
Gnomadrs10748842
Varsomers10748842
LitVarrs10748842
Maprs10748842
PheGenIrs10748842
Biobankrs10748842
1000 genomesrs10748842
hgdprs10748842
ensemblrs10748842
geneviewrs10748842
scholarrs10748842
googlers10748842
pharmgkbrs10748842
gwascentralrs10748842
openSNPrs10748842
23andMers10748842
SNPshotrs10748842
SNPdbers10748842
MSV3drs10748842
GWAS Ctlgrs10748842
GMAF0.1084
Max Magnitude0
? (C;C) (C;T) (T;T) 28


rs10748842 is a SNP in the neuregulin 3 NRG3 gene.

Based on a study of 1515 Ashkenazi Jewish individuals, including 285 parent-child trios, 173 unrelated cases, and 487 unrelated controls, three SNPs (rs10883866, rs10748842, and rs6584400) were found to be associated with the "delusion" factor as a quantitative trait in schizophrenia, even though no SNP in this study withstood multiple test correction for association with the binary schizophrenia phenotype itself. After replication in an independent set of 153 Ashkenazi Jewish samples, the empirical study-wide significance across all 9 factors studied was estimated to be p = 2.7x10e-3.[PMID 19118813OA-icon.png]



[PMID 20713722OA-icon.png] Common genetic variation in Neuregulin 3 (NRG3) influences risk for schizophrenia and impacts NRG3 expression in human brain

OMIM605533
DescNEUREGULIN 3; NRG3
Variant
Relatedalso



[PMID 28256518OA-icon.png] Effects of RET, NRG1 and NRG3 Polymorphisms in a Chinese Population with Hirschsprung Disease.