rs1121980
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | average |
| (C;T) | 2.5 | Slight increase (1.67x) in risk for obesity |
| (T;T) | 3 | Moderate increase (2.76x) in risk for obesity |
| Reference | GRCh38 38.1/141 |
| Chromosome | 16 |
| Position | 53775335 |
| Gene | FTO |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1121980 |
| dbSNP (classic) | rs1121980 |
| ClinGen | rs1121980 |
| ebi | rs1121980 |
| HLI | rs1121980 |
| Exac | rs1121980 |
| Gnomad | rs1121980 |
| Varsome | rs1121980 |
| LitVar | rs1121980 |
| Map | rs1121980 |
| PheGenI | rs1121980 |
| Biobank | rs1121980 |
| 1000 genomes | rs1121980 |
| hgdp | rs1121980 |
| ensembl | rs1121980 |
| geneview | rs1121980 |
| scholar | rs1121980 |
| rs1121980 | |
| pharmgkb | rs1121980 |
| gwascentral | rs1121980 |
| openSNP | rs1121980 |
| 23andMe | rs1121980 |
| SNPshot | rs1121980 |
| SNPdbe | rs1121980 |
| MSV3d | rs1121980 |
| GWAS Ctlg | rs1121980 |
| GMAF | 0.3682 |
| Max Magnitude | 3 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs1121980, a SNP in the FTO gene, showed the strongest association of several SNPs in the region with early onset obesity in a study of ~1,000 Caucasians.
The odds ratio for the rs1121980(T) risk allele was 1.66 (CI:1.3-2.01); and the odds ratios for heterozygotes and homozygotes (rs1121980(T;T)) were estimated (with a correct p<0.0001) at 1.67 (CI: 1.22-2.27) and 2.76 (CI: 1.88-4.03), respectively. [PMID 18159244
]
Note that although rs1121980 showed the strongest association, it is in a block in the FTO gene of at least 5 other SNPs that are in linkage disequilibrium (r2>=0.88 for all). The other 5 SNPs are:
[PMID 18379722] This SNP is also associated with (severe) obesity in a study of 927 Japanese patients.
[PMID 19164386] obesity and type-2 diabetes
| GWAS snp | |
|---|---|
| PMID | [PMID 18454148]
|
| Trait | Body mass index |
| Title | Common variants near MC4R are associated with fat mass, weight and risk of obesity |
| Risk Allele | |
| P-val | 4.0000000000000001E-8 |
| Odds Ratio | 0.06 [0.04-0.08] unit increase in log(BMI) |
[PMID 19322589] Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study
[PMID 19553294] Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene
[PMID 19812171] Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies
[PMID 20075932] Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese
[PMID 21248185] Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals
[PMID 22355368] Longitudinal Replication Studies of GWAS Risk SNPs Influencing Body Mass Index over the Course of Childhood and Adulthood
[PMID 18256137] Regulation of Fto/Ftm gene expression in mice and humans.
[PMID 18487448] Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population.
[PMID 18599522] FTO variants are associated with obesity in the Chinese and Malay populations in Singapore.
[PMID 19079261] Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
[PMID 19474294] Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
[PMID 20017965] Identifying association under a previous linkage peak on chromosome 16 for body mass index using cross-sectional and longitudinal data of the Framingham Heart Study.
[PMID 20017980] A multilevel linear mixed model of the association between candidate genes and weight and body mass index using the Framingham longitudinal family data.
[PMID 20018076] Tests for candidate-gene interaction for longitudinal quantitative traits measured in a large cohort.
[PMID 20299471] FTO genetic variation and association with obesity in West Africans and African Americans.
[PMID 20442772] Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia.
[PMID 20824172] Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study.
[PMID 21102551] Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort.
[PMID 21115529] Genetics and genomics of human ageing.
[PMID 22049296] A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI.
[PMID 23935507] Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry
[PMID 24106974] Association between fat mass and obesity-associated (FTO) gene and hip fracture susceptibility
| GWAS snp | |
|---|---|
| PMID | [PMID 24097068]
|
| Trait | HDL cholesterol |
| Title | Discovery and refinement of loci associated with lipid levels. |
| Risk Allele | A |
| P-val | 7E-9 |
| Odds Ratio | .02 [NR] unit decrease |
[PMID 26445370] Genetic Effects on Longitudinal Changes from Healthy to Adverse Weight and Metabolic Status - The HUNT Study
[PMID 26726774] Gender-Dependent Association of FTO Polymorphisms with Body Mass Index in Mexicans.
[PMID 26843521] A comprehensive meta-analysis of case-control association studies to evaluate polymorphisms associated with the risk of differentiated thyroid carcinoma.
[PMID 26935496] The Frequencies of Haplotypes of FTO Gene Variants and Their Association with the Distribution of Body Fat in Non-Obese Poles.
[PMID 27820839] FTO Gene Polymorphism Is Associated with Type 2 Diabetes through Its Effect on Increasing the Maximum BMI in Japanese Men.
[PMID 30099472] Fat Mass and Obesity-Associated (FTO) Gene Polymorphisms Are Associated with Risk of Intervertebral Disc Degeneration in Chinese Han Population: A Case Control Study.
[PMID 30275878] Direct and indirect genetic effects on triglycerides through omics and correlated phenotypes.
[PMID 30822753] Effects of fat mass and obesity-associated (FTO) gene polymorphisms on binge eating in women with binge-eating disorder: The moderating influence of attachment style.
[PMID 32384785] Applicability of Obesity-Related SNPs and their Effect Size Measures Defined on Populations with European Ancestry for Genetic Risk Estimation among Roma.
[PMID 32788640] Genetic markers and continuity of healthy metabolic status: Tehran cardio-metabolic genetic study (TCGS).
