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rs139709573

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;G) 5 Possible link to late-onset Alzheimer's, at least in Icelanders
(G;G) 0 common/normal


Make rs139709573(A;A)
ReferenceGRCh38.p2 38.2/147
Chromosome15
Position101646763
GeneTM2D3
is asnp
is mentioned by
dbSNPrs139709573
ClinGenrs139709573
ebirs139709573
HLIrs139709573
Exacrs139709573
Varsomers139709573
Maprs139709573
PheGenIrs139709573
hapmaprs139709573
1000 genomesrs139709573
hgdprs139709573
ensemblrs139709573
gopubmedrs139709573
geneviewrs139709573
scholarrs139709573
googlers139709573
pharmgkbrs139709573
gwascentralrs139709573
openSNPrs139709573
23andMers139709573
23andMe allrs139709573
SNP Nexus

SNPshotrs139709573
SNPdbers139709573
MSV3drs139709573
GWAS Ctlgrs139709573
Max Magnitude5
rs139709573, also known as Pro155Leu or P155L, is a rare variant in the TM2D3 gene on chromosome 15.

At least in Icelanders, although not proven statistically for other Europeans (where it's ten-fold rarer), the rare rs139709573(A) allele was associated with increased risk and earlier onset of late-onset Alzheimer's disease, with an odds ratio of 7.5 (CI:3.5–15.9), p = 6.6x10e-9.[1]