rs1554973

plus

Geno	Mag	Summary
(C;C)	2	increased risk for chorionic plate inflammation
(C;T)		increased risk for chorionic plate inflammation
(T;T)		normal

Reference

GRCh38 38.1/141

Chromosome

9

Position

117718534

Gene

TLR4

is a	snp
is	mentioned by
dbSNP	rs1554973
dbSNP (classic)	rs1554973
ClinGen	rs1554973
ebi	rs1554973
HLI	rs1554973
Exac	rs1554973
Gnomad	rs1554973
Varsome	rs1554973
LitVar	rs1554973
Map	rs1554973
PheGenI	rs1554973
Biobank	rs1554973
1000 genomes	rs1554973
hgdp	rs1554973
ensembl	rs1554973
geneview	rs1554973
scholar	rs1554973
google	rs1554973
pharmgkb	rs1554973
gwascentral	rs1554973
openSNP	rs1554973
23andMe	rs1554973
SNPshot	rs1554973
SNPdbe	rs1554973
MSV3d	rs1554973
GWAS Ctlg	rs1554973

GMAF

0.326

Max Magnitude

2

?

(C;C) (C;T) (T;T)

28

rs1554973 is a SNP near the toll-like receptor 4 TLR4 gene.

A study of 109 pregnant women focusing on TLR4 SNPs associated with chorionic plate inflammation concluded that rs1554973 was associated with increased risk when present in the fetal genome. The risk allele's increased odds ratio for clinically significant inflammation was 4.95 (CI: 3.0-5.6, p = .005). [PMID 18928988]

[PMID 19554026 ] Genetic association of Toll-like receptor 4 with cervical cytokine concentrations during pregnancy

[PMID 19134200 ] No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis.

[PMID 20049212 ] Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS).

[PMID 20200442 ] Sequence variants in the TLR4 and TLR6-1-10 genes and prostate cancer risk. Results based on pooled analysis from three independent studies.

[PMID 20463618 ] Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.

[PMID 21704385 ] Interaction between interleukin-1 receptor 2 and Toll-like receptor 4, and cervical cytokines.

[PMID 23161283 ] SNPs in toll-like receptor (TLR) genes as new genetic alterations associated with congenital toxoplasmosis?

[PMID 24971461 ] Polymorphisms in the Inflammatory Pathway Genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG Are Associated with Susceptibility of Inflammatory Bowel Disease in a Danish Cohort

[PMID 25360682 ] Polymorphisms of an innate immune gene, toll-like receptor 4, and aggressive prostate cancer risk: a systematic review and meta-analysis

[PMID 24776844] Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease

[PMID 30208882 ] Genetically determined high activities of the TNF-alpha, IL23/IL17, and NFkB pathways were associated with increased risk of ankylosing spondylitis.