|?|| (C;C) (C;T) (T;T) ||28|
This SNP, a variant in the CHEK2
gene, is 1 of 25 SNPs reported to represent independently minor, but cumulatively significant, increased risk for breast cancer
. [PMID 17341484
For details of all 25 SNPs in this group, along with the two methods used to calculate overall risk estimates for breast cancer, refer to the SNPedia breast cancer entry.
For this particular SNP, the risk (minor) allele is (C).
[PMID 18086781] rs17879961 one of 3 SNPs associated with increased risk of lung cancer
not provided Li-Fraumeni syndrome 2 Colorectal cancer Cancer of multiple types Prostate cancer Hereditary cancer-predisposing syndrome not specified Familial cancer of breast Breast and colorectal cancer
| Variation || info |
not provided Li-Fraumeni syndrome 2 Colorectal cancer, susceptibility to Cancer of multiple types, susceptibility to Prostate cancer, susceptibility to Hereditary cancer-predisposing syndrome not specified Familial cancer of breast Breast and colorectal cancer, susceptibility to
Inc. OMIM Allelic Variant UniProtKB (protein)
RCV000255649.1, RCV000005936.2, RCV000005937.2, RCV000005938.2, RCV000005939.2, RCV000116018.8, RCV000120555.1, RCV000144596.3, RCV000210131.1, RCV000212410.1,
[PMID 17517688] Uncommon CHEK2 mis-sense variant and reduced risk of tobacco-related cancers: case control study.
[PMID 19442246] The associations of sequence variants in DNA-repair and cell-cycle genes with cancer risk: genotype-phenotype correlations.
|| [PMID 24880342]
|| Lung cancer
|| Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer.
| Risk Allele
| Odds Ratio
|| 1.67 [1.43-1.92]
[PMID 25798211] The c.470 T > C CHEK2 missense variant increases the risk of differentiated thyroid carcinoma in the Great Poland population