rs1800169

plus

Geno	Mag	Summary
(A;A)		normal
(A;G)	0	normal
(G;G)		greater relative benefit of iloperidone to schizophrenics

Reference

GRCh38 38.1/141

Chromosome

11

Position

58624028

Gene	CNTF, ZFP91-CNTF

is a	snp
is	mentioned by
dbSNP	rs1800169
dbSNP (classic)	rs1800169
ClinGen	rs1800169
ebi	rs1800169
HLI	rs1800169
Exac	rs1800169
Gnomad	rs1800169
Varsome	rs1800169
LitVar	rs1800169
Map	rs1800169
PheGenI	rs1800169
Biobank	rs1800169
1000 genomes	rs1800169
hgdp	rs1800169
ensembl	rs1800169
geneview	rs1800169
scholar	rs1800169
google	rs1800169
pharmgkb	rs1800169
gwascentral	rs1800169
openSNP	rs1800169
23andMe	rs1800169
SNPshot	rs1800169
SNPdbe	rs1800169
MSV3d	rs1800169
GWAS Ctlg	rs1800169

GMAF

0.1244

Max Magnitude

0

?

(A;A) (A;G) (G;G)

28

rs1800169 is a SNP in the ciliary neurotrophic factor CNTF gene.

In a study of 417 patients with schizophrenia, 279 were treated with iloperidone while 138 were treated with placebo. Iloperidone significantly improved in 6 clinical scores versus placebo. rs1800169(G;G) homozygotes showed greater improvement with iloperidone compared to placebo for 3 of the clinical scores compared to carriers of a rs1800169(A) allele.[PMID 18303965]

[PMID 19833146] Sex-specific effects of CNTF, IL6 and UCP2 polymorphisms on weight gain

[PMID 16696750] Variation in the ciliary neurotrophic factor gene and muscle strength in older Caucasian women.

[PMID 20368905 ] New atypical antipsychotics for schizophrenia: iloperidone.