rs2227631
| Orientation | plus |
| Stabilized | plus |
| Make rs2227631(A;A) |
| Make rs2227631(A;G) |
| Make rs2227631(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 7 |
| Position | 101126257 |
| Gene | SERPINE1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs2227631 |
| dbSNP (classic) | rs2227631 |
| ClinGen | rs2227631 |
| ebi | rs2227631 |
| HLI | rs2227631 |
| Exac | rs2227631 |
| Gnomad | rs2227631 |
| Varsome | rs2227631 |
| LitVar | rs2227631 |
| Map | rs2227631 |
| PheGenI | rs2227631 |
| Biobank | rs2227631 |
| 1000 genomes | rs2227631 |
| hgdp | rs2227631 |
| ensembl | rs2227631 |
| geneview | rs2227631 |
| scholar | rs2227631 |
| rs2227631 | |
| pharmgkb | rs2227631 |
| gwascentral | rs2227631 |
| openSNP | rs2227631 |
| 23andMe | rs2227631 |
| SNPshot | rs2227631 |
| SNPdbe | rs2227631 |
| MSV3d | rs2227631 |
| GWAS Ctlg | rs2227631 |
| GMAF | 0.4408 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
[PMID 21752301
] Significant associations of PAI-1 genetic polymorphisms with osteonecrosis of the femoral head
[PMID 22133274] Polymorphisms of PAI-1 and platelet GP Ia may associate with impairment of renal function and thrombocytopenia in Puumala hantavirus infection
[PMID 16172282] Comprehensive survey of common genetic variation at the plasminogen activator inhibitor-1 locus and relations to circulating plasminogen activator inhibitor-1 levels.
[PMID 16424345] Plasminogen activator inhibitor-1 gene: selection of tagging single nucleotide polymorphisms and association with coronary heart disease.
[PMID 17656673] Association of plasminogen activator inhibitor (PAI)-1 (SERPINE1) SNPs with myocardial infarction, plasma PAI-1, and metabolic parameters: the HIFMECH study.
[PMID 18853133] Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.
[PMID 18974842] Gender differences in genetic risk profiles for cardiovascular disease.
[PMID 19360663] Genetic evidence implicating multiple genes in the MET receptor tyrosine kinase pathway in autism spectrum disorder.
[PMID 19368854] No association between the promoter polymorphisms of PAI-1 gene and sporadic Alzheimer's disease in Chinese Han population.
[PMID 19526059] Polymorphic variation of genes in the fibrinolytic system and the risk of ovarian cancer.
[PMID 22503724] Promoter polymorphisms of SERPINE1 are associated with the antidepressant response to depression in Alzheimer's disease.
| GWAS snp | |
|---|---|
| PMID | [PMID 22990020]
|
| Trait | Plasminogen activator inhibitor type 1 levels (PAI-1) |
| Title | Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation. |
| Risk Allele | |
| P-val | 3E-24 |
| Odds Ratio | .07 [NR] unit increase |
[PMID 24135164] Genetic polymorphisms in plasminogen activator inhibitor-1 predict susceptibility to steroid-induced osteonecrosis of the femoral head in Chinese population
[PMID 24355042] Association of five common polymorphisms in the plasminogen activator inhibitor-1 gene with primary ovarian insufficiency
[PMID 25231632] Pai-1 Gene Variants and COC Use Are Associated with Stroke Risk: A Case-Control Study in the Han Chinese Women
[PMID 27510778] [Association of single nucleotide polymorphisms in PAI-1 with breast cancer susceptibility and prognosis].
