rs2832407

plus

Geno	Mag	Summary
(C;C)	2	topiramate may work to reduce heavy drinking best for this genotype

Make rs2832407(A;A)

Make rs2832407(A;C)

Reference

GRCh38 38.1/141

Chromosome

21

Position

29595188

Gene	GRIK1, GRIK1-AS2

is a	snp
is	mentioned by
dbSNP	rs2832407
dbSNP (classic)	rs2832407
ClinGen	rs2832407
ebi	rs2832407
HLI	rs2832407
Exac	rs2832407
Gnomad	rs2832407
Varsome	rs2832407
LitVar	rs2832407
Map	rs2832407
PheGenI	rs2832407
Biobank	rs2832407
1000 genomes	rs2832407
hgdp	rs2832407
ensembl	rs2832407
geneview	rs2832407
scholar	rs2832407
google	rs2832407
pharmgkb	rs2832407
gwascentral	rs2832407
openSNP	rs2832407
23andMe	rs2832407
SNPshot	rs2832407
SNPdbe	rs2832407
MSV3d	rs2832407
GWAS Ctlg	rs2832407

GMAF

0.4481

Max Magnitude

2

The rs2832407(C) allele has inconsistently been linked to alcoholism and its treatment. Nonetheless, a 2014 report based on 138 patients concludes that rs2832407(C;C) individuals show a greater decrease than non-carriers (of a rs2832407(C) allele) in the number of heavy drinking days per week when taking topiramate at a dose of 200 mg/daily.[PMID 24525690 ] A follow-up study done 3 and 6 months after treatment seemed to mostly confirm the topiramate benefit preferentially to rs2832407(C;C) individuals.[PMID 25581656 ]

?

(A;A) (A;C) (C;C)

28

[PMID 19320626 ] Association of Markers in the 3' Region of the GluR5 Kainate Receptor Subunit Gene to Alcohol Dependence.

[PMID 19331489 ] A preliminary pharmacogenetic investigation of adverse events from topiramate in heavy drinkers

[PMID 24525690 ] Topiramate Treatment for Heavy Drinkers: Moderation by a GRIK1 Polymorphism