|?|| (A;A) (A;G) (G;G) ||28|
associated with breast cancer
risk [PMID 16685266
] and ovarian cancer
More specifically: carriers of two rs2854344(A) alleles have a 25% reduced risk of developing ovarian cancer compared to carriers of two rs2854344(G) alleles, in a survey of ~5,000 women from the US, UK, and Denmark. [PMID 17047088]
[PMID 18431743] showed no association with ovarian cancer risk 4,624 invasive epithelial ovarian cancer cases and 8,113 controls of white non-Hispanic origin ovarian cancer
[PMID 18174243] Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population.
[PMID 18281541] Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survival.
[PMID 19124506] Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.
[PMID 19258477] Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk.
[PMID 21641967] Genetic susceptibility to sporadic ovarian cancer: A systematic review.