|| normal risk for endometrial/breast cancer
|| 1.3x higher risk for endometrial cancer (in Chinese women)
|| 1.2x higher breast cancer risk; 1.3x higher risk for endometrial cancer (in Chinese women)
|?|| (C;C) (C;T) (T;T) ||28|
shows an association with breast cancer
in a British study involving ~2300 patients. The odds ratio for the (T;T) vs (C;C) homozygotes is 1.22 (CI: 1.02-1.47, p=0.013).[PMID 18174243
[PMID 15026335] found a significant association between rs34330 (-79C/T) and prostate cancer
[PMID 21454826] found higher odds for endometrial cancer among 1,200+ Chinese patients associated with rs34330, with an odds ratio of 1.33 (CI: 1.06-1.66) and 1.51 (CI: 1.16-1.94) for the (C;T) and (T;T) genotypes, respectively, compared with the (C;C) genotype.
see also omim 176807
|Desc||CYCLIN-DEPENDENT KINASE INHIBITOR 1B; CDKN1B|
] Allelic variant at -79 (C>T) in CDKNIB (p27Kip1) confers an increased risk of thyroid cancer and alters mRNA levels
] Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes.
[PMID 17459456] A common variant of the p16(INK4a) genetic region is associated with physical function in older people.
[PMID 17601350] A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
[PMID 17908995] Genetic variants in cell cycle control pathway confer susceptibility to lung cancer.
[PMID 19124506] Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.
[PMID 19258477] Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk.
[PMID 19667240] p27kip1-838C>A single nucleotide polymorphism is associated with restenosis risk after coronary stenting and modulates p27kip1 promoter activity.
[PMID 20452958] Single-nucleotide polymorphisms in the p53 signaling pathway.
|| [PMID 23273568]
|| Systemic lupus erythematosus
|| Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
| Risk Allele
| Odds Ratio
[PMID 28667701] The functional variant rs34330 of CDKN1B is associated with risk of neuroblastoma.