|(A;A)||1.5||0.85x decreased risk for Alzheimer's disease|
|(A;G)||1.5||0.85x decreased risk for Alzheimer's disease|
A study of over 5,000 Alzheimer's disease patients (and over 10,000 controls) found a slight protective effect of the (A) allele of this SNP. rs3851179(A) carriers had a slightly decreased risk for Alzheimer's disease, with an odds ratio of 0.85 (CI: 0.8-0.9, p=1.9x10e-8).10.1038/ng.440[PMID 20554627] The association of this SNP and late-onset Alzheimer's disease was replicated over a total of another 1829 cases (and 2576 controls).
|Title||Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease|
|Odds Ratio||1.16 [1.11-1.22]|
[PMID 20697030] Meta-analysis Confirms CR1, CLU, and PICALM as Alzheimer Disease Risk Loci and Reveals Interactions With APOE Genotypes
[PMID 20951388] Genetic association of PICALM polymorphisms with Alzheimer's disease in Han Chinese
[PMID 21321396] Replication of BIN1 Association with Alzheimer's Disease and Evaluation of Genetic Interactions
[PMID 21912625] An exploratory study on CLU, CR1 and PICALM and Parkinson disease
[PMID 22715855] Lack of association of the PICALM rs3851179 polymorphism with Parkinson's Disease in the Greek Population
[PMID 20451875] Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans.
[PMID 20738160] Association analysis between the rs11136000 single nucleotide polymorphism in clusterin gene, rs3851179 single nucleotide polymorphism in clathrin assembly lymphoid myeloid protein gene and the patients with schizophrenia in the Chinese population.
[PMID 20739100] Genetic variations in the CLU and PICALM genes are associated with cognitive function in the oldest old.
[PMID 21297266] Implication of a genetic variant at PICALM in Alzheimer's disease patients and centenarians.
[PMID 21347408] Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease.
[PMID 21358043] PICALM and CR1 variants are not associated with sporadic Alzheimer's disease in Chinese patients.
[PMID 21379329] Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.
[PMID 21390209] Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease.
[PMID 21726919] CR1 genotype is associated with entorhinal cortex volume in young healthy adults.
[PMID 22015308] Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese population.
[PMID 23036585] Exploratory analysis of seven Alzheimer's disease genes: disease progression
[PMID 23040034] Lack of association between PICALM rs3851179 polymorphism and Alzheimer's disease in Chinese population and APOEε4-negative subgroup
|qualified_impact||Insufficiently evaluated pathogenic|
[PMID 22402018] Implication of common and disease specific variants in CLU, CR1, and PICALM
[PMID 23419238] Allele-specific polymerase chain reaction for the detection of Alzheimer's disease-related single nucleotide polymorphisms
[PMID 22943764] Identification and confirmation of an exonic splicing enhancer variation in exon 5 of the Alzheimer disease associated PICALM gene
[PMID 23572399] PICALM Gene rs3851179 Polymorphism Contributes to Alzheimer's Disease in an Asian Population
[PMID 23650005] Lack of association of CR1, PICALM and CLU gene polymorphisms with Alzheimer disease in a Polish population
[PMID 24618820] Genetics of PICALM Expression and Alzheimer's Disease
[PMID 22005930] Genome-wide association study of Alzheimer's disease with psychotic symptoms.
[PMID 23180304] Genetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer's disease.
[PMID 24788522] Genetic variation at the CELF1 (CUGBP, elav-like family member 1 gene) locus is genome-wide associated with Alzheimer's disease and obesity
[PMID 25169757] An intronic PICALM polymorphism, rs588076, is associated with allelic expression of a PICALM isoform
[PMID 20558387] Genetic variation and neuroimaging measures in Alzheimer disease.
[PMID 25189118] Late-onset Alzheimer's risk variants in memory decline, incident mild cognitive impairment, and Alzheimer's disease
[PMID 26434199] LACK OF ASSOCIATIONS BETWEEN CLU AND PICALM GENE POLYMORPHISMS AND ALZHEIMER'S DISEASE IN A TURKISH POPULATION
[PMID 26611835] Meta-analysis of the Association between Alzheimer Disease and Variants in GAB2, PICALM, and SORL1.
[PMID 26889634] Investigation of Genetic Variants Associated with Alzheimer Disease in Parkinson Disease Cognition.
[PMID 28316001] Associations of polymorphisms in the candidate genes for Alzheimer's disease BIN1, CLU, CR1 and PICALM with gestational diabetes and impaired glucose tolerance.
[PMID 28567584] rs3851179 Polymorphism at 5' to the PICALM Gene is Associated with Alzheimer and Parkinson Diseases in Brazilian Population.