rs429358(C;C)
| one of 2 snps relevant to classifying APOE genotype |
| Is a | genotype |
| of | rs429358 |
| Gene | APOE |
| Chromosome | 19 |
| Position | 44,908,684 |
| mentioned | by |
| Magnitude | 1.2 |
| Repute | Bad |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 1.2 | one of 2 snps relevant to classifying APOE genotype |
| (C;T) | >3x increased risk for Alzheimer's; 1.4x increased risk for heart disease | |
| (T;T) | 0 | common |
One of 2 snps which is necessary to identify ApoE4.
rs429358(C;C) individuals have an increased risk of developing Alzheimer's disease [PMID 15956169].
APOE4 differences only affect the brain after age 60. The memory changes that occur from 20 to 60 do not seem to be connected to APOE4 at all. [1]
[2]
Patients with Alzheimer's disease who have at least one ApoE4 allele were found to benefit from a therapy that was ineffective in those who lacked [3]
Inheritance of the rs1799724(T) allele (a variant in another gene, TNF) appears to synergistically increase the risk of Alzheimer's in APOE4 carriers and is associated with altered CSF Abeta42 levels [PMID 15895461]
[PMID 17192785] The researchers found that on testing DNA samples from 1,086 well-characterized Alzheimer's disease cases, a single SNP (rs4420638) lying 14 kb distal to the ApoE locus has a powerful association with late-onset AD (corrected p value was 5.3 x 10 e-34). No other SNP showed as robust an association. The authors estimated that people with two ApoE4 copies, such as a person with the rs429358(C;C) genotype, have a 25-fold increased risk for developing the disease compared to ApoE3/ApoE3 carriers. [4]
