| Geno
|
Mag
|
Summary
|
| (C;C)
|
0
|
common/normal
|
| (T;T)
|
4
|
APOE E2/E2 most likely; lower Alzheimer's risk
|
[PMID 20838585
] rs445925 can be used as a proxy for rs7412, based on a correlation of ~0.76 - 0.87 in at least some populations. This is of use in genotyping ApoE status, since although rs7412 tags the ApoE2 allele directly, it (rs7412) is missing from many genotyping chips (such as some of those used by AncestryDNA, for example).
In dbSNP orientation, rs445925(T) corresponds to rs7412(T) and therefore, at least when the association is true, establishes the presence of an ApoE2 allele. Note that this association does not hold in African (and African-American) populations.
| GWAS snp
|
| PMID
|
[PMID 20838585]
|
| Trait
|
|
| Title
|
Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa Heart Study
|
| Risk Allele
|
G
|
| P-val
|
9E-19
|
| Odds Ratio
|
11.96 [9.33-14.59] % SD increase
|
[PMID 21977987] Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses
| GWAS snp
|
| PMID
|
[PMID 21909108]
|
| Trait
|
|
| Title
|
Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque.
|
| Risk Allele
|
G
|
| P-val
|
0.000004
|
| Odds Ratio
|
1.2200 [1.12-1.32]
|
| GWAS snp
|
| PMID
|
[PMID 23031429]
|
| Trait
|
Apolipoprotein Levels
|
| Title
|
A Genome-Wide Association Study of Monozygotic Twin-Pairs Suggests a Locus Related to Variability of Serum High-Density Lipoprotein Cholesterol.
|
| Risk Allele
|
G
|
| P-val
|
2E-14
|
| Odds Ratio
|
.15 [0.11-0.19] unit increase
|
| GWAS snp
|
| PMID
|
[PMID 22916037]
|
| Trait
|
Metabolite levels
|
| Title
|
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
|
| Risk Allele
|
|
| P-val
|
6E-42
|
| Odds Ratio
|
NR NR
|
[PMID 23092954] SHAVE: shrinkage estimator measured for multiple visits increases power in GWAS of quantitative traits.
[PMID 26520901] Impact of carotid atherosclerosis loci on cardiovascular events
] rs445925 can be used as a proxy for rs7412, based on a correlation of ~0.76 - 0.87 in at least some populations. This is of use in genotyping ApoE status, since although rs7412 tags the ApoE2 allele directly, it (rs7412) is missing from many genotyping chips (such as some of those used by AncestryDNA, for example).
