| Geno
|
Mag
|
Summary
|
| (C;C)
|
1.5
|
Higher B12 levels in women
|
| (C;T)
|
1
|
Normal B12 levels
|
| (T;T)
|
1
|
Normal B12 levels
|
From [PMID 18776911
]: We identified a strong association (p = 5.36 x 10(-17)) between rs492602 in the FUT2 gene and plasma vitamin B(12) levels in a genome-wide scan (n = 1,658) and an independent replication sample (n = 1,059) from the Nurses' Health Study. Women homozygous for the rs492602(C) allele (in dbSNP orientation) had higher B(12) levels. This allele is in strong linkage disequilibrium with the FUT2 nonsecretor variant encoding W143X, suggesting a plausible mechanism for altered B(12) absorption and plasma levels.
| OMIM | 612542 |
| Desc | VITAMIN B12 PLASMA LEVEL QUANTITATIVE TRAIT LOCUS 1; B12QTL1 |
| Variant | |
| Related | also |
[PMID 19744961] Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway
| GWAS snp
|
| PMID
|
[PMID 20686565]
|
| Trait
|
|
| Title
|
Biological, clinical and population relevance of 95 loci for blood lipids.
|
| Risk Allele
|
G
|
| P-val
|
2E-10
|
| Odds Ratio
|
1.2700 None
|
[PMID 19474294] Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
[PMID 23468552] Genetic variants influencing biomarkers of nutrition are not associated with cognitive capability in middle-aged and older adults.
]: We identified a strong association (p = 5.36 x 10(-17)) between rs492602 in the FUT2 gene and plasma vitamin B(12) levels in a genome-wide scan (n = 1,658) and an independent replication sample (n = 1,059) from the Nurses' Health Study. Women homozygous for the rs492602(C) allele (in dbSNP orientation) had higher B(12) levels. This allele is in strong linkage disequilibrium with the FUT2 nonsecretor variant encoding W143X, suggesting a plausible mechanism for altered B(12) absorption and plasma levels.
