rs700651

rs700651 associated with increased risk of developing intracranial aneurysm.

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(A;A)	1	Normal risk of aneurysm
(A;G)	1.5	~1.11x increased risk of intracranial aneurysm
(G;G)	2	~1.23x increased risk of intracranial aneurysm

Reference

GRCh38 38.1/141

Chromosome

2

Position

197766990

Gene

BOLL

is a	snp
is	mentioned by
dbSNP	rs700651
dbSNP (classic)	rs700651
ClinGen	rs700651
ebi	rs700651
HLI	rs700651
Exac	rs700651
Gnomad	rs700651
Varsome	rs700651
LitVar	rs700651
Map	rs700651
PheGenI	rs700651
Biobank	rs700651
1000 genomes	rs700651
hgdp	rs700651
ensembl	rs700651
geneview	rs700651
scholar	rs700651
google	rs700651
pharmgkb	rs700651
gwascentral	rs700651
openSNP	rs700651
23andMe	rs700651
SNPshot	rs700651
SNPdbe	rs700651
MSV3d	rs700651
GWAS Ctlg	rs700651

GMAF

0.3021

Max Magnitude

2

?	(A;A) (A;G) (G;G)	28

a larger meta-analysis in 2013 gave rs700651 a per allele OR of 1.11; 95% CI 1.06 -1.18. See PMC3716358

23andMe blog aneurysm

• rs700651 2 G 1.18x risk 1.56x risk
• rs10958409 8 A 1.37x risk 1.79x risk
• rs1333040 9 T 1.29x risk 1.67x risk

GWAS snp
PMID	[PMID 18997786]
Trait	Intracranial aneurysm
Title	Susceptibility loci for intracranial aneurysm in European and Japanese populations
Risk Allele	G
P-val	4E-8
Odds Ratio	1.24 [1.15-1.34]

OMIM	612586
Desc	ANEURYSM, INTRACRANIAL BERRY, 9
Variant
Related	also

[PMID 20395613] Confirmation of an association of single-nucleotide polymorphism rs1333040 on 9p21 with familial and sporadic intracranial aneurysms in Japanese patients.

Increased risk of intracranial (brain aneurysm) with certain SNPs. rs700651(G;G) associated with 1.56x risk of developing an intracranial aneurysm (IA). Heterozygote risk is 1.18x. Other SNPs associated with increased risk of developing IA include rs1333040 and rs10958409.

rs10958409 is located on chromosome 9; rs1333040 is located on chromosome 8; rs700651 is located on chromosome 2.

Unfortunately, the first sign of an intracranial aneurysm is rupture. Catastrophic bleeding and death may result. Specific knowledge of risk may influence screening decision. More information: Intracranial aneurysm screening: indications and advice for practice. [PMID 15664544]. [PMID 22476622] Increased risk of stroke in oral contraceptive users carried replicated genetic variants: a population-based case-control study in China.

[PMID 30823506] Genomic Variations in Susceptibility to Intracranial Aneurysm in the Korean Population.