We have typed the IVS 1 rs737865 and 3' rs615599 sites and also included a novel IVS 1 indel polymorphism. We report that the schizophrenia-associated haplotype is significantly heterogeneous in populations worldwide. [PMID 15098000]
may affect non-Hodgkin lymphoma, anxiety-related personality traits
Also mentioned in these PMIDs
[PMID 19369177] Association of the 3' Region of COMT with Schizophrenia in Taiwan
[PMID 19290789] Association studies of catechol-O-methyltransferase (COMT) gene with schizophrenia and response to antipsychotic treatment
[PMID 21940152] The impact of COMT gene polymorphisms on suicidality in treatment resistant major depressive disorder - A European Multicenter Study
[PMID 19077118] Genetic variants in COMT and neurocognitive impairment in families of patients with schizophrenia
[PMID 12802784] A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain.
[PMID 15931594] An entropy-based statistic for genomewide association studies.
[PMID 16027741] Catechol-O-methyltransferase haplotypes are associated with psychosis in Alzheimer disease.
[PMID 16232322] COMT genetic variation confers risk for psychotic and affective disorders: a case control study.
[PMID 16483362] The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression.
[PMID 16525418] Association of the Val158Met catechol O-methyltransferase genetic polymorphism with panic disorder.
[PMID 16816420] Nonlinear tests for genomewide association studies.
[PMID 16837108] Haplotypes in cathechol-O-methyltransferase gene confer increased risk for psychosis in Alzheimer disease.
[PMID 17363961] Clinical involvement of catechol-O-methyltransferase polymorphisms in schizophrenia spectrum disorders: influence on the severity of psychotic symptoms and on the response to neuroleptic treatment.
[PMID 17427186] Association analysis of COMT polymorphisms and schizophrenia in a Chinese Han population: a case-control study.
[PMID 17466074] Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study.
[PMID 17482701] No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population.
[PMID 17630406] Dopamine genes and schizophrenia: case closed or evidence pending?
[PMID 17707347] Genetic variation in catechol-O-methyltransferase: effects on working memory in schizophrenic patients, their siblings, and healthy controls.
[PMID 18081002] Association of catechol-O-methyltransferase variants with loudness dependence of auditory evoked potentials.
[PMID 18384078] Association study of candidate variants of COMT with neuroticism, anxiety and depression.
[PMID 18436194] Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes.
[PMID 18574484] The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase.
[PMID 18704099] Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence.
[PMID 18715757] Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.
[PMID 19071221] Impact of interacting functional variants in COMT on regional gray matter volume in human brain.
[PMID 19329282] Meta-analysis of association between genetic variants in COMT and schizophrenia: an update.
[PMID 19365560] Low enzymatic activity haplotypes of the human catechol-O-methyltransferase gene: enrichment for marker SNPs.
[PMID 19721400] Association between COMT gene and Chinese male schizophrenic patients with violent behavior.
[PMID 19911060] Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.
[PMID 20531207] The impact of catechol-O-methyltransferase SNPs and haplotypes on treatment response phenotypes in major depressive disorder: a case-control association study.
[PMID 20667552] Catechol-o-methyltransferase gene modulation on suicidal behavior and personality traits: review, meta-analysis and association study.
[PMID 21172166] Pharmacogenetics of antidepressant response.
[PMID 21204206] Evaluation of 64 candidate single nucleotide polymorphisms as risk factors for neural tube defects in a large Irish study population.
[PMID 21462137] [An association study of COMT gene polymorphisms with schizophrenia].
[PMID 21600957] COMT and age at onset in mood disorders: a replication and extension study.
[PMID 21656904] Association between polymorphisms in catechol-O-methyltransferase (COMT) and cocaine-induced paranoia in European-American and African-American populations.
|qualified_impact||Insufficiently evaluated pharmacogenetic|
[PMID 24382678] Association between maternal COMT gene polymorphisms and fetal neural tube defects risk in a Chinese population
[PMID 22705295] Association of MB-COMT polymorphisms with schizophrenia-susceptibility and symptom severity in an African cohort.
[PMID 23178897] The catechol-O-methyltransferase gene (COMT) and cognitive function from childhood through adolescence.
[PMID 23351565] Potential role of membrane-bound COMT gene polymorphisms in female depression vulnerability.
[PMID 23598060] Association study of polymorphisms in the alpha 7 nicotinic acetylcholine receptor subunit and catechol-o-methyl transferase genes with sensory gating in first-episode schizophrenia
[PMID 27228319] A Tetra-Primer Amplification Refractory System Technique for the Cost-Effective and Novel Genotyping of Eight Single-Nucleotide Polymorphisms of the Catechol-O-Methyltransferase Gene.
[PMID 28273278] Catechol-O-methyltransferase (COMT) polymorphisms modulate working memory in individuals with schizophrenia and healthy controls.