|2x increased risk for Type-2 diabetes|
|| Normal (lower) risk of Type 2 Diabetes and Gestational Diabetes.
|| 1.4x increased risk for diabetes (and perhaps colon cancer).
|| 2x increased risk for Type-2 diabetes
This genotype doubles the risk of Type-2 diabetes, [PMID 17671651] and also Gestational Diabetes. Also increased risk of colo-rectal cancer. Reduced insulin secretion in the pancreas. This has been confirmed in most races. In African Americans it even affects young people.