|(A;A)||0||normal risk for T2D|
|(A;G)||1.9||1.6x risk for T2D|
|(G;G)||2||3.2x risk for T2D|
In a study of 500 unrelated Caucasian T2D patients, the rs7923837(G) allele was overrepresented; the odds ratio was 1.57 (CI: 1.08-2.27, p=0.017). In this population, the population attributable risk for this allele was estimated to be 33%.[PMID 18231124]
In a study of ~400 Japanese T2D patients, rs7923837(G) was also associated with type-2 diabetes (odds ratio 1.66, CI: 1.28-2.15, p=0.00014). Heterozygous and homozygous carriers of the risk allele had odds ratios of 1.57 (95% CI 1.15-2.16, p=0.0050) and 3.16 (95% CI 1.40-7.16, p=0.0038) relative to non-carriers.[PMID 17971426]PMID 20043145] Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study
[PMID 20802253] Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion
[PMID 21059810] Meta-analysis of the effect of HHEX gene polymorphism on the risk of type 2 diabetes
|Title||Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.|
|Odds Ratio||1.1000 [1.08-1.11]|
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[PMID 17928989] Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population.
[PMID 18039816] A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study.
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[PMID 18654633] Simultaneous analysis of all SNPs in genome-wide and re-sequencing association studies.
[PMID 18689899] Exchangeable models of complex inherited diseases.
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[PMID 19172244] The risk allele load accelerates the age-dependent decline in beta cell function.
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[PMID 19741467] Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.
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[PMID 20126254] Rare variants create synthetic genome-wide associations.
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[PMID 20580033] Replication of recently described type 2 diabetes gene variants in a South Indian population.
[PMID 21278902] Genetic risk profiling for prediction of type 2 diabetes.
[PMID 24468095] Genetic variants for type 2 diabetes and new-onset cancer in Chinese with type 2 diabetes
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