rs9574

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(C;C)		EPCR H1 diplotype; reduced risk of VTE?
(C;G)		EPCR H1 haplotype; reduced risk of VTE?
(G;G)		normal risk for VTE

Reference

GRCh38 38.1/141

Chromosome

20

Position

35176829

Gene

PROCR

is a	snp
is	mentioned by
dbSNP	rs9574
dbSNP (classic)	rs9574
ClinGen	rs9574
ebi	rs9574
HLI	rs9574
Exac	rs9574
Gnomad	rs9574
Varsome	rs9574
LitVar	rs9574
Map	rs9574
PheGenI	rs9574
Biobank	rs9574
1000 genomes	rs9574
hgdp	rs9574
ensembl	rs9574
geneview	rs9574
scholar	rs9574
google	rs9574
pharmgkb	rs9574
gwascentral	rs9574
openSNP	rs9574
23andMe	rs9574
SNPshot	rs9574
SNPdbe	rs9574
MSV3d	rs9574
GWAS Ctlg	rs9574

GMAF

0.449

Max Magnitude

0

?	(C;C) (C;G) (G;G)	28

rs9574 is a SNP that can indicate haplotype H1 of the PROCR gene. The protein product of the PROCR gene activates a part of the anticoagulation pathway. While the rs9574(G) allele could indicate haplotypes H2, H3 or H4, the rs9574(C) allele distinctly tags (identifies) the H1 haplotype.[PMID 17849044]

The H1 haplotype (and thus rs9574(C)) has been reported to be associated with a reduced risk of venous thromboembolism (VTE), with an odds ratio of 0.59, CI: 0.41–0.84.[PMID 15116250] Two other groups have not found this association to be statistically valid in the populations they studied.[PMID 14576048, PMID 15304035]

[PMID 30383853] Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke.