TYMS
From SNPedia
| is a | gene |
| is | mentioned by |
| Full name | thymidylate synthetase |
| EntrezGene | 7298 |
| PheGenI | 7298 |
| VariationViewer | 7298 |
| ClinVar | TYMS |
| GeneCards | TYMS |
| dbSNP | 7298 |
| Diseases | TYMS |
| SADR | 7298 |
| HugeNav | 7298 |
| wikipedia | TYMS |
| TYMS | |
| gopubmed | TYMS |
| EVS | TYMS |
| HEFalMp | TYMS |
| MyGene2 | TYMS |
| 23andMe | TYMS |
| UniProt | P04818 |
| Ensembl | ENSG00000176890 |
| OMIM | 188350 |
| # SNPs | 16 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| rs1001761 | 0 | 662,103 | |
| rs1059394 | 0 | 672,792 | |
| rs151264360 | 0 | 673,444 | |
| rs16430 | 0 | 673,444 | |
| rs16948305 | 0 | 668,465 | |
| rs2612100 | 0 | 672,363 | |
| rs2790 | 0 | 673,086 | |
| rs2847149 | 0 | 666,371 | |
| rs2853533 | 0 | 658,064 | |
| rs2853539 | 0 | 659,829 | |
| rs2853542 | 0 | 657,685 | |
| rs34489327 | 0 | 673,451 | |
| rs34743033 | 0 | 657,646 | |
| rs45445694 | 0 | 657,646 | |
| rs502396 | 0 | 659,236 | |
| rs699517 | 0 | 673,016 |
The TYMS gene encodes the enzyme thymidylate synthase, which is the primary target of 5-fluorouracil as used in chemotherapeutic treatment of various cancers. Variations in the the TYMS gene can influence risk for toxicity, including:
- rs16430, in the 3' UTR of the gene; a 6bp insertion/deletion polymorphism
- rs45445694, a 28bp VNTR
- rs34743033, a G>C SNP in 2nd repeat of 3R allele
