Triglycerides

Triglycerides are an important measure of the heart health. They make up a large part of the body's fat and are also found in the bloodstream. They are associated with increased risk of coronary artery diseases (CAD) or heart diseases. People with hypertriglyceridemia (HTG) have elevated blood levels of fatty acids.

Due to the health impacts triglycerides are used as a disease/trait category in the Catalog of Published Genome-Wide Association Studies, the GWAS Catalog of the National Human Genome Research Institute.

More reading:

• Boston scientists say triglycerides play key role in heart health, Boston Globe, June 18 2014 [1]

[PMID 24097068] Discovery and refinement of loci associated with lipid levels.

[PMID 23726366] Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations.

[PMID 23031429] A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol.

[PMID 22171074] A genome-wide association and gene-environment interaction study for serum triglycerides levels in a healthy Chinese male population.

[PMID 21909109] Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.

[PMID 21386085] A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.

[PMID 20864672] Genetic variants influencing circulating lipid levels and risk of coronary artery disease.

[PMID 20686565] Biological, clinical and population relevance of 95 loci for blood lipids.

[PMID 20139978] Genome-wide association study of hematological and biochemical traits in a Japanese population.

[PMID 19074352] A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection.

[PMID 19060911] Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.

[PMID 19060906] Common variants at 30 loci contribute to polygenic dyslipidemia.

[PMID 18193044] Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.

[PMID 18193046] Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides.

[PMID 18193043] Newly identified loci that influence lipid concentrations and risk of coronary artery disease.

[PMID 17463246] Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.