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FGFR2

From SNPedia

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EntrezGene2263
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VariationViewer2263
ClinVarFGFR2
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dbSNP2263
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# SNPs98
 Max MagnitudeChromosome positionSummary
rs1047100121,538,644
rs10510097121,568,362
rs1057519036121,520,092
rs1057519037121,520,084
rs1057519038121,520,076
rs1057519039121,520,049
rs1057519040121,519,995
rs1057519041121,517,465
rs1057519042121,517,396
rs1057519043121,517,391
rs1057519044121,517,390
rs1057519045121,498,522
rs1057519046121,498,521
rs1057519047121,488,055
rs1057519791121,518,810
rs1057519795121,488,002
rs1057519796121,496,546
rs1057519797121,496,705
rs1057519798121,498,528
rs1057519799121,498,556
rs1057519800121,498,562
rs1057519854121,488,063
rs1057519900
rs1057519901
rs1057520027121,488,005
rs1057520028121,515,283
rs1057520029121,488,003
rs1057520044121,498,597
rs1064796413
rs1064796452
rs10736303121,574,943
rs1078806121,579,461
rs11199993121,531,750
rs11200012121,572,901
rs11200014121,575,416
rs121913474
rs121913475121,519,989
rs121913476121,498,520
rs1219134770121,515,289
rs1219134780121,515,280
rs1219184870121,517,378
rs1219184880121,517,379
rs1219184890121,517,385
rs1219184900121,517,342
rs1219184910121,517,371
rs1219184920121,517,372
rs1219184930121,517,420
rs1219184940121,517,363
rs1219184950121,517,382
rs1219184960121,517,377
... further results


A relatively small increase in risk for sporadic postmenopausal ER+ breast cancer in European women has been reported to be highly significant for a haplotype of intron 2 of the FGFR2 gene.[PMID 17529973]

The primary SNP associated with this risk is rs1219648, however more recently, two neighboring SNPs (rs2981578 and rs7895676) from this same region have been postulated based on experimental evidence to be the causative factors. The minor alleles of these SNPs appear to increase FGFR2 expression and thereby to increase the risk for breast cancer.10.1371/journal.pbio.0060108


blog snps in COL11A1, LMNA, FGFR1, FGFR2, TRPS, BRAF, FLNA affect normal variation in facial features.