|| 2.2x risk type-2 diabetes
|| 1.2x risk type-2 diabetes
|?|| (C;C) (C;T) (T;T) ||28|
has been reported in a large study to be associated with type-2 diabetes
The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with heterozygotes is 1.18 (CI 1.04-1.34), and for homozygotes, 2.17 (CI 1.6-2.95). [PMID 17554300]
[PMID 18633108] When combined, each additional risk allele from rs9465871, rs10811661, rs4402960, and rs13266634 increased the risk for type 2 diabetes by 1.24-fold (P = 2.85 x 10(-7)) or for combined IFG/type 2 diabetes by 1.21-fold (P = 6.31 x 10(-11)) in Chinese Hans
|Desc||DIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM|
] Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.
[PMID 19862325] PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.
[PMID 19931040] Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies.
[PMID 20847106] Association of a cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1 (CDKAL1) polymorphism with elevated hemoglobin A(1)(c) levels and the prevalence of metabolic syndrome in Japanese men: interaction with dietary energy intake.
[PMID 21368910] Heterogeneity of genetic associations of CDKAL1 and HHEX with susceptibility of type 2 diabetes mellitus by gender.
|| Insufficiently evaluated pathogenic