Stroke, also known clinically as a cerebrovascular accident, is defined as a disturbance in the flow of blood to the brain and the consequent loss of brain function. It is one of the leading causes of death worldwide; more information is available at Wikipedia.
SNPs affecting the risk of one or more types of stroke include the following:
- rs17696736, in the SH2B3 gene
- rs16851055, in the SPSB4 gene
- rs12646447, in the PITX2 gene
- rs12425791, in the NINJ2 gene
- rs6797312, in the SERPIN1 gene
- rs4792143, in the FLJ45455 gene
- rs2200733, in the NR gene
- rs2084898, in the TRIM29 gene
- rs1401296, in the PROC gene
- rs1364044, in the ADAMTS12 gene
- rs556621, in the SUPT3H gene
- rs469568, in the ADAMTS2 gene
- rs225132, in the ERRFI1 gene
- rs173686, in the CSPG2 gene, linked to intracranial aneurysm
- rs161802, in the PARK7 gene
- rs6025, known as F5 Leiden
- rs5443, in the GNB3 gene
One or more SNPs in the following genes have also been linked to stroke risk:
In Asian patients, two SNPs in the PRKCH gene have been linked to cerebral infarctions:
Note that there are two common forms of strokes, hemorrhagic and ischemic. Basically, ischemic strokes result from a blockage, whereas hemorrhagic result from the bursting of an aneurysmal artery in the brain (and consequent loss of blood and pressure to the brain). SNPs associated with increased risk for aneurysms are therefore potentially associated with hemorrhagic stroke risk.
[PMID 24262325] Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
[PMID 22990015] A genome-wide association study identifies a gene network of ADAMTS genes in the predisposition to pediatric stroke.
[PMID 22384361] Genome-wide association analysis of ischemic stroke in young adults.
[PMID 22306652] Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke.
[PMID 22941190] Common variants at 6p21.1 are associated with large artery atherosclerotic stroke.
[PMID 21957438] Genomic risk profiling of ischemic stroke: results of an international genome-wide association meta-analysis.
[PMID 21940970] Siblings with ischemic stroke study: results of a genome-wide scan for stroke loci.
[PMID 21155030] Association of the adiponectin gene variations with risk of ischemic stroke in a Korean population.
[PMID 19403135] Identification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome-wide association study.
[PMID 19369658] Genomewide association studies of stroke.
[PMID 18991354] Risk variants for atrial fibrillation on chromosome 4q25 associate with ischemic stroke.
[PMID 17434096] A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release.