rs187238

minus

Geno	Mag	Summary
(C;C)	1.8	hypertension not a risk factor for sudden cardiac death
(C;G)	1.8	hypertension not a risk factor for sudden cardiac death
(G;G)	2.5	hypertension increases risk 3.75x for sudden cardiac death

Reference

GRCh38 38.1/141

Chromosome

11

Position

112164265

Gene

IL18

is a	snp
is	mentioned by
dbSNP	rs187238
dbSNP (classic)	rs187238
ClinGen	rs187238
ebi	rs187238
HLI	rs187238
Exac	rs187238
Gnomad	rs187238
Varsome	rs187238
LitVar	rs187238
Map	rs187238
PheGenI	rs187238
Biobank	rs187238
1000 genomes	rs187238
hgdp	rs187238
ensembl	rs187238
geneview	rs187238
scholar	rs187238
google	rs187238
pharmgkb	rs187238
gwascentral	rs187238
openSNP	rs187238
23andMe	rs187238
SNPshot	rs187238
SNPdbe	rs187238
MSV3d	rs187238
GWAS Ctlg	rs187238

GMAF

0.2277

Max Magnitude

2.5

rs187238, also known as -137 G/C, is a SNP in the interleukin 18 IL18 gene.

Based on studying autopsies of 700 men in the Helsinki Sudden Death Study, there was a significant interaction between IL-18 genotype and hypertension impacting on the risk of sudden cardiac death (SCD) due to coronary heart disease (CHD). Among rs187238(G;G) homozygotes, hypertension was a major risk factor for SCD due to CHD (adjusted odds ratio 3.75, CI:1.78-7.91, p < 0.001) and hypertension also associated with larger coronary atherosclerotic plaque areas (p = 0.002) and the occurrence of complicated plaques (adjusted OR 8.38, CI: 2.39-29.33, p < 0.001). Among rs187238(C) allele carriers, hypertension was not a significant risk factor for CHD-related SCD or CAD and did not associate with the development of coronary atherosclerotic plaques.[PMID 19687159]

[PMID 19455410] Interleukin 18 promoter variants (-137G>C and -607C>A) in patients with chronic hepatitis C: association with treatment response

[PMID 20331879 ] Association between IL-18 gene polymorphisms and biopsy-proven giant cell arteritis

[PMID 20097272] Interleukin-18 promoter polymorphisms and risk of ischemic stroke

[PMID 21241672] Interleukin-18 Promoter Polymorphisms and Risk of Parkinson's disease in a Han Chinese Population

[PMID 21470492] Interleukin-18 promoter polymorphisms in patients with systemic lupus erythematosus

[PMID 21510800] Association Between Promoter Variants of Interleukin-18 and Schizophrenia in a Han Chinese Population

[PMID 21611751] Interleukin-18 promoter polymorphism and asthma risk: a meta-analysis

[PMID 22008665] The associations of IL-18 serum levels and promoter polymorphism with tacrolimus pharmacokinetics and hepatic allograft dysfunction in Chinese liver transplantation recipients

[PMID 21962565] Promoter variants in IL18 are associated with onset of depression in patients previously exposed to stressful-life events

[PMID 22664470] Genes of the Interleukin-18 Pathway Are Associated With Susceptibility to Barrett's Esophagus and Esophageal Adenocarcinoma

[PMID 15896202] Interleukin-18-promoter polymorphisms are not relevant in rheumatoid arthritis.

[PMID 16078996 ] Association study of functional genetic variants of innate immunity related genes in celiac disease.

[PMID 16443795] Analysis of polymorphisms of the interleukin-18 gene in type 1 diabetes and Hardy-Weinberg equilibrium testing.

[PMID 16542373 ] Interleukin 18 and human immunodeficiency virus type I infection in adolescents and adults.

[PMID 16759385 ] Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA).

[PMID 16909454 ] NeuroD1 gene and interleukin-18 gene polymorphisms in type 1 diabetes in Dalmatian population of Southern Croatia.

[PMID 17355643 ] Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population.

[PMID 17765248] Interleukin-18 promoter polymorphism associates with the occurrence of sudden cardiac death among Caucasian males: the Helsinki Sudden Death Study.

[PMID 17854431] Interleukin-18 gene polymorphisms and haplotypes in patients with oral lichen planus: a study in an ethnic Chinese cohort.

[PMID 17919265] Polymorphism of interleukin-18 promoter influences the onset of kidney graft function after transplantation.

[PMID 18043444] Interleukin (IL)-18 polymorphism 133C/G is associated with severe respiratory syncytial virus infection.

[PMID 18599493] Promoter polymorphism of interleukin-18 in angiographically proven coronary artery disease.

[PMID 19073159] Interleukin-18 promoter polymorphisms and risk of late onset Alzheimer's disease.

[PMID 19178691 ] Novel polymorphism of interleukin-18 associated with greater inflammation after cardiac surgery.

[PMID 19229765] Interleukin-18 gene (IL18) promoter polymorphisms in patients with rheumatoid arthritis.

[PMID 19961892] Impact of interleukin-18 polymorphisms-607 and -137 on clinical characteristics of renal cell carcinoma patients.

[PMID 20304021] Haplotype analysis of the interleukin-18 gene in Czech patients with allergic disorders.

[PMID 20478055 ] Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study.

[PMID 20818961] Inflammatory mediators gene polymorphisms in preeclampsia.

[PMID 21840518] Analysis of interleukin-18 promoter polymorphisms and changes in interleukin-18 serum levels underscores the involvement of interleukin-18 in recurrent spontaneous miscarriage.

[PMID 21969001 ] Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality.

[PMID 22325058] Association of polymorphisms in interleukin-18 and interleukin-28B with Hepatitis B recurrence after liver transplantation in Chinese Han population.

[PMID 22386125] Interleukin-18 promoter polymorphisms and risk of idiopathic recurrent pregnancy loss in a Tunisian population.

[PMID 23153245 ] Association of IL-18 polymorphisms with rheumatoid arthritis and systemic lupus erythematosus in Asian populations: a meta-analysis

[PMID 23546966] Effect of IL-18 gene promoter polymorphisms on prostate cancer occurrence and prognosis in Han Chinese population

[PMID 24446726 ] Association Between Interleukin 18 Polymorphisms and Alopecia Areata in Koreans

[PMID 23073298] The IL18 gene and Hashimoto thyroiditis in children.

[PMID 23238919] Association between interleukin-18 polymorphisms and systemic lupus erythematosus: a meta-analysis.

[PMID 23302036] Gender-specific association of the interleukin 18 gene with symptomatic gallstone disease.

[PMID 23557801] Interleukin 18 (IL18) gene promoter polymorphisms are associated with type 1 diabetes mellitus in Brazilian patients.

[PMID 23587914] Interleukin-18 gene polymorphisms and rheumatoid arthritis: a meta-analysis.

[PMID 24969483] IL-18 genetic polymorphisms may contribute to the pathogenesis of tuberculosis among Asians: a meta-analysis of case-control studies

[PMID 25192895] Association of IL-18 promoter gene polymorphisms with rheumatoid arthritis: a meta-analysis

[PMID 25446437] Association of IL-1, IL-18, and IL-33 gene polymorphisms with late-onset Alzheimer׳s disease in a Hunan Han Chinese population

[PMID 25690033 ] Genetic variant in interleukin-18 is associated with idiopathic recurrent miscarriage in chinese han population

[PMID 25712187] Donor IL-18 rs5744247 polymorphism as a new biomarker of tacrolimus elimination in Chinese liver transplant patients during the early post-transplantation period: results from two cohort studies

[PMID 26042207 ] Association between interleukin-18 gene promoter (- 607C/A and - 137G/C) polymorphisms and chronic hepatitis C virus infections: A meta-analysis

[PMID 26041375] A gene-disease association study of IL18 in thyroid cancer: genotype and haplotype analyses

[PMID 26116895] Interleukin-18 promoter -607 C/A and -137 G/C polymorphisms and susceptibility to type 1 diabetes: A meta-analysis

[PMID 26486291] ANALYSIS OF POLYMORPHISMS IN THE INTERLEUKIN 18 GENE PROMOTOR (-137 G/C AND -607 C/A) IN PATIENTS INFECTED WITH HEPATITIS C VIRUS FROM THE BRAZILIAN AMAZON

[PMID 27470888] [Association between interleukin-18 gene polymorphisms and hepatocellular carcinoma caused by hepatitis B virus].

[PMID 27559091] Influence of cytokine gene polymorphisms on proinflammatory/anti-inflammatory cytokine imbalance in premature coronary artery disease.

[PMID 28580570] IL16 and IL18 gene polymorphisms in women with gestational diabetes.

[PMID 29061223] Association between donor and recipient Interleukin-18 gene polymorphisms and the risk of infection after liver transplantation.

[PMID 29129846] The IL18 Promoter Polymorphism, rs1946518, Is Associated with the Risk of Periodontitis in Japanese Women: The Kyushu Okinawa Maternal and Child Health Study.

[PMID 30059753] Association of IL18 genetic polymorphisms with increased risk of Biliary atresia susceptibility in Southern Chinese children.

[PMID 30208882 ] Genetically determined high activities of the TNF-alpha, IL23/IL17, and NFkB pathways were associated with increased risk of ankylosing spondylitis.

[PMID 30728751 ] Inflammasome Genes' Polymorphisms in Egyptian Chronic Hepatitis C Patients: Influence on Vulnerability to Infection and Response to Treatment.

[PMID 31301271] Lack of significant effect of interleukin-18 gene variants on tuberculosis susceptibility in the Polish population.

[PMID 31448710] Frequency of Inflammasome Nlrp1/Nlrp3 Gene Receptor Polimorphisms And The Interleukins IL-1ß/IL-18 Gene Polymorphisms And Their Association With Severity Score In Sickle Cell Disease Patients.

[PMID 31660404 ] Impacts of Interleukin-18 Polymorphisms on the Incidence of Delayed-Onset Cytomegalovirus Infection in a Cohort of Kidney Transplant Recipients.

[PMID 32106113] Influence of Polymorphisms in the Interleukin-18 Gene on Allergic Rhinitis: A Meta-Analysis.

[PMID 32425678 ] Polymorphisms of genes encoding cytokines predict the risk of high-grade bladder cancer and outcomes of BCG immunotherapy.

[PMID 31992083] IL1β, IL18, NFKB1 and IFNG gene interactions are associated with severity of rheumatoid arthritis: A pilot study.