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ADIPOQ

From SNPedia
is agene
is mentioned by
Full nameadiponectin, C1Q and collagen domain containing
EntrezGene9370
PheGenI9370
VariationViewer9370
ClinVarADIPOQ
GeneCardsADIPOQ
dbSNP9370
DiseasesADIPOQ
SADR9370
HugeNav9370
wikipediaADIPOQ
googleADIPOQ
gopubmedADIPOQ
EVSADIPOQ
HEFalMpADIPOQ
MyGene2ADIPOQ
23andMeADIPOQ
UniProtQ15848
EnsemblENSG00000181092
OMIM605441
# SNPs32
 Max MagnitudeChromosome positionSummary
rs10635370186,856,286
rs10635380186,856,394
rs10635390186,857,603
rs1219178150186,854,303
rs124959410186,850,391
rs1445262090186,854,564
rs15012992186,853,334
rs168611940186,841,636
rs168612050186,843,845
rs168612090186,845,325
rs173005391186,841,671
rs173665680186,852,664
rs173666530186,853,027
rs173667430186,854,300
rs178468660186,852,957
rs1820520186,842,993
rs20829400186,856,375
rs22417662186,853,103
rs22417670186,853,407
rs2667292186,841,685
rs37742610186,853,770
rs37742620186,854,025
rs67739570186,855,916
rs745778620186,843,903
rs76271280186,851,010
rs76491210186,850,996
rs8223910186,846,014
rs8223930186,848,537
rs8223940186,848,939
rs8223950186,849,018
rs8223960186,849,088
rs98822050186,852,609

The ADIPOQ gene on chromosome 3 encodes adiponection (APN), a 30kDa glycoprotein composed of 244 amino acids. Sometimes known in literature as the "guardian angel cytokine", adiponection may play a key role in the pathogenesis of obesity-associated cancers along with other diseases such as cardiovascular disease and type-2 diabetes, and in general, having higher levels of adiponectin are a good thing compared to lower levels.

Polymorphisms in the ADIPOQ gene may influence cancer risk. A 2016 review [PMID 27144066OA-icon.png] of these associations includes: