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Atrial fibrillation

From SNPedia

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Schematic diagram of normal sinus rhythm for a human heart as seen on ECG. In atrial fibrillation, however, the P waves, which represent depolarization of the atria, are absent.
Name Atrial fibrillation
ICD10 I48
ICD9 427.31
MedlinePlus 000184
MeshID D001281

Atrial fibrillation (AF), a common type of heart arrhythmia, is a major risk factor for stroke. About 15 percent of all strokes are attributable to atrial fibrillation. Anticoagulants such as Warfarin, as well as beta blockers and calcium channel blockers, may be prescribed to reduce the risk of stroke.

How common is atrial fibrillation? Data from the Framingham Heart Study, which followed over 8,000 Massachusetts residents from 1966-1999, indicate that the average lifetime risk after age 40 was 26% for men and 23% for women, and that the risk remained relatively constant as individuals grew older. [PMID 15313941]

In 2018, a large meta-analysis identified 97 loci significantly associated with atrial fibrillation; some of the genes are shown below.10.1038/s41588-018-0133-9

Various genes have been associated with atrial fibrillation: