CYP2B6
From SNPedia
| is a | gene |
| is | mentioned by |
| Full name | cytochrome P450, family 2, subfamily B, polypeptide 6 |
| EntrezGene | 1555 |
| PheGenI | 1555 |
| VariationViewer | 1555 |
| ClinVar | CYP2B6 |
| GeneCards | CYP2B6 |
| dbSNP | 1555 |
| Diseases | CYP2B6 |
| SADR | 1555 |
| HugeNav | 1555 |
| CYPANC | cyp2b6 |
| wikipedia | CYP2B6 |
| CYP2B6 | |
| gopubmed | CYP2B6 |
| EVS | CYP2B6 |
| HEFalMp | CYP2B6 |
| MyGene2 | CYP2B6 |
| 23andMe | CYP2B6 |
| UniProt | P20813 |
| Ensembl | ENSG00000197408 |
| OMIM | 123930 |
| # SNPs | 28 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| rs10403955 | 0 | 41,003,533 | |
| rs1042389 | 0 | 41,018,248 | |
| rs12721646 | 0 | 41,009,202 | |
| rs12721655 | 0 | 41,004,377 | |
| rs139801276 | 0 | 41,004,303 | |
| rs186335453 | 0 | 41,004,158 | |
| rs2279343 | 2 | 41,009,358 | |
| rs2279344 | 0 | 41,009,578 | |
| rs2279345 | 0 | 41,009,797 | |
| rs281864907 | 0 | 41,004,015 | |
| rs28399497 | 0 | 41,009,358 | |
| rs28399499 | 0 | 41,012,316 | |
| rs3211371 | 0 | 41,016,810 | |
| rs34097093 | 0 | 41,012,465 | |
| rs34223104 | 0 | 40,991,224 | |
| rs35303484 | 0 | 40,991,441 | |
| rs36079186 | 0 | 41,007,013 | |
| rs371424910 | 0 | 41,007,057 | |
| rs373489637 | 0 | 41,006,968 | |
| rs3745274 | 2 | 41,006,936 | |
| rs4802101 | 0 | 40,990,556 | |
| rs4802104 | 0 | 41,015,622 | |
| rs4803419 | 0 | 41,006,887 | |
| rs58425034 | 0 | 41,009,060 | |
| rs7260329 | 0 | 41,015,733 | |
| rs8109848 | 0 | 41,016,164 | |
| rs8192709 | 0 | 40,991,369 | |
| rs8192719 | 0 | 41,012,868 |
The protein encoded by the CYP2B6 gene is the primary metabolizer of a number of drug substrates, such as bupropion, cyclophosphamide, ifosfamide, pethidine, efavirenz, nevirapine, ketamine and propofol. [PMID 17073575]
SNPs in CYP2B6 may thus influence the efficacy of such drugs. For example, the effectiveness of bupropion, a commonly used smoking cessation drug, has been reported to vary depending on CYP2B6 genotype.
Mirtazapine concentration is affected by CYP2B6, which could be associated with efficacy [PMID 22926595].
Note that there are over 100 CYP2B6 SNPs known, with numerous complex haplotypes and distinct ethnic frequencies, making CYP2B6 one of the most polymorphic cytochrome p450 genes in humans. [PMID 17638512]
