Glimepiride
From SNPedia
Glimepiride (original trade name Amaryl) is an orally available medium-to-long-acting sulfonylurea antidiabetic drug. Glimepiride is indicated to treat type-2 diabetes; its mode of action is to increase insulin production by the pancreas. It is not used for type-1 diabetes because in type-1 diabetes the pancreas is not able to produce insulin.Wikipedia
| Genotype/Genoset | Diplotype | Gene | Drug Use/Category/Class | Medical Field | Summary | Descriptive Sentence |
|---|---|---|---|---|---|---|
| gs309 | WT/WT | G6PD | Diabetes | Endocrinology | Normal Response Expected | You do not appear to carry any G6PD mutations linked to an unwanted side effect (hemolytic anemia). |
| gs307 | Carrier | G6PD | Diabetes | Endocrinology | Consider Alternatives | You carry a G6PD mutation that might lead to an unwanted side effect (hemolytic anemia) when taking glimepiride; due to variable expression (i.e. in females), enzymatic testing for G6PD activity is advisable. |
| gs308 | G6PD-deficient | G6PD | Diabetes | Endocrinology | Consider Alternatives | You carry a G6PD mutation linked to an unwanted side effect (hemolytic anemia) when taking glimepiride; use caution and consider non-sulfonylurea alternatives. |
