Gs126
From SNPedia
| Gs126 | |
|---|---|
| Magnitude | 3.5 |
| Repute | Bad |
| Summary | Poor warfarin metabolizer |
| Criteria | Gs126/criteria |
Approximately 7-10% of people are poor metabolizers of the popular anticoagulant Warfarin and would probably need a decreased dosage. This due to mutations in rs1799853 or rs1057910 causing an inactive CYP2C9 gene. You are at increased risk of drug-induced side effects due to diminished drug elimination. Prodrugs dependent on CYP2C9 metabolism may fail to generate the active form of the drug.
