Gs306
From SNPedia
| Gs306 | |
|---|---|
| Magnitude | 6.5 |
| Repute | Bad |
| Summary | Poor metabolizer of fluoropyrimidines (e.g. 5-fluorouracil, capecitabine or tegafur). |
| Criteria | Gs306/criteria |
This genoset predicts the presence of two DPYD gene mutations associated with nonfunctional alleles, and therefore greatly increased toxicity if administered chemotherapeutic fluoropyridimines such as 5-fluorouracil and capecitabine. Patients with this genoset are at high risk according to the FDA of toxic (even lethal) reactions and should avoid these drugs.
