HLA-DRB1
| is a | gene |
| is | mentioned by |
| Full name | major histocompatibility complex, class II, DR beta 1 |
| EntrezGene | 3123 |
| PheGenI | 3123 |
| VariationViewer | 3123 |
| ClinVar | HLA-DRB1 |
| GeneCards | HLA-DRB1 |
| dbSNP | 3123 |
| Diseases | HLA-DRB1 |
| SADR | 3123 |
| HugeNav | 3123 |
| wikipedia | HLA-DRB1 |
| HLA-DRB1 | |
| gopubmed | HLA-DRB1 |
| EVS | HLA-DRB1 |
| HEFalMp | HLA-DRB1 |
| MyGene2 | HLA-DRB1 |
| 23andMe | HLA-DRB1 |
| UniProt | P01911 |
| Ensembl | ENSG00000196126 |
| OMIM | 142857 |
| # SNPs | 8 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| rs1059553 | 0 | 32,489,219 | |
| rs148699775 | 0 | 32,581,815 | |
| rs34817315 | 0 | 32,489,219 | |
| rs674313 | 0 | 32,610,305 | |
| rs707953 | 0 | 32,589,729 | |
| rs7451962 | 0 | 32,614,658 | |
| rs9269955 | 0 | 32,584,361 | |
| rs9270305 | 0 | 32,589,729 |
HLA-DRB1 is one the HLA genes that make up the human major histocompatibility complex, surface antigens that regulate the immune system, contributing the beta-1 subunit of the HLA-DR receptor, along with B3-B5. It is connected to a number of immune conditions.
The DRB1*1501 allele is linked to HLA-DRA rs3135388(A), and this was used to connect *1501 to a 1.99x risk of MS in 7740 subjects by the International Multiple Sclerosis Genetics Consortium (2007). HLA-DRB1*0401 and HLA-DRB1*0408 (odds ratio: 5.15), but not other HLA alleles, were strongly associated with neutralizing antibodies to interferon-B for MS by Hoffmann et al. (2008)
HLA-DRB1*04:04-DQB1*03:02 and HLA-DRB1*08-DQB1*04 haplotypes have risk of type 1 diabetes, which is further increased by HLA-B*39. [PMID 24055898]
Cervical Cancer: DRB1*0301, *0403,*0404, *0803, *1312 and *1502 were associated with a increased risk and DRB1*03 and DRB1*08 had negative correlations in all 12 studies of Chinese subgroups. [PMID 24551099]
DRB1*0301 is a risk for Parkinson's in Chinese Han; HLA-DRB1*0406 may be protective. [PMID 23139797]
HLA-DRB1*04, *0401, *0404, *0405 and *0410 are risk factors for rheumatoid arthritis in Chinese.
DRB1*08:03 allele is signifigantly associated with primary biliary cirrhosis.
HLA-DRB1*1101 is more common in sarcoidosis.
Hep B Vaccine: DRB1*08 was positively associated with the hepatitis B vaccination responder phenotype, mostly due to DRB1*0804. DRB1*03 and DRB1*0701 were found in 54% of nonresponders, 41% of medium responders, and 28% of high responders. Li et al. (2009)
DRB1*1301 was negatively associated with age-related macular degeneration independent of linkage by Goverdhan et al. (2005).
Gottenberg et al. (2003) confirmed the association of Sjogren syndrome with DRB1*03 and DQB1*02 in patients with anti-SSA and anti-SSB antibodies.
HLA-DRB1*07:01 is associated with asparaginase allergies.
Tag SNPs for HLA-DRB1 antitypes on the 1M Illumina chip[edit]
| HLA | SNP | r2 | HLA_FRQ | SNP_FRQ |
|---|---|---|---|---|
| DRB1*03:01 | rs2187668 | 0.077 | 0.08 | |
| DRB1*03:04 | rs2517623 | 0.004 | 0.000 | 0.01 |
| DRB1*04:03 | rs3763305 | 0.061 | 0.010 | 0.06 |
| DRB1*04:06 | rs9391637 | 0.011 | 0.001 | 0.01 |
| DRB1*04:07 | rs4947332 | 0.047 | 0.010 | 0.02 |
| DRB1*04:08 | rs17501267 | 0.077 | 0.010 | 0.04 |
| DRB1*04:09 | rs9267658 | 0.003 | 0.000 | 0.06 |
| DRB1*04:10 | rs6902544 | 0.007 | 0.000 | 0.01 |
| DRB1*04:11 | rs3817964 | 0.010 | 0.001 | 0.06 |
| DRB1*04:37 | rs7742120 | 0.003 | 0.000 | 0.07 |
| DRB1*08:02 | rs9501626 | 0.039 | 0.004 | 0.09 |
| DRB1*08:03 | rs2395148 | 0.039 | 0.003 | 0.03 |
| DRB1*08:04 | rs7356880 | 0.066 | 0.003 | 0.03 |
| DRB1*08:06 | rs9469063 | 0.013 | 0.000 | 0.03 |
| DRB1*11:02 | rs28366191 | 0.016 | 0.003 | 0.05 |
| DRB1*11:03 | rs17208888 | 0.052 | 0.004 | 0.07 |
| DRB1*11:04 | rs17208888 | 0.059 | 0.010 | 0.07 |
| DRB1*11:06 | rs11754099 | 0.011 | 0.001 | 0.03 |
| DRB1*11:08 | rs9469024 | 0.017 | 0.000 | 0.01 |
| DRB1*12:01 | rs3129888 | 0.054 | 0.010 | 0.10 |
| DRB1*13:04 | rs3130666 | 0.012 | 0.000 | 0.02 |
| DRB1*13:05 | rs17208888 | 0.010 | 0.001 | 0.07 |
| DRB1*14:02 | rs7761890 | 0.017 | 0.002 | 0.02 |
| DRB1*14:05 | rs3129727 | 0.011 | 0.000 | 0.02 |
| DRB1*14:06 | rs12055568 | 0.017 | 0.001 | 0.03 |
| DRB1*14:07 | rs11575840 | 0.012 | 0.000 | 0.02 |
| DRB1*14:15 | rs3129727 | 0.016 | 0.000 | 0.02 |
| DRB1*16:02 | rs9270986 | 0.034 | 0.003 | 0.09 |
