HLA-E
From SNPedia
| is a | gene |
| is | mentioned by |
| Full name | major histocompatibility complex, class I, E |
| EntrezGene | 3133 |
| PheGenI | 3133 |
| VariationViewer | 3133 |
| ClinVar | HLA-E |
| GeneCards | HLA-E |
| dbSNP | 3133 |
| Diseases | HLA-E |
| SADR | 3133 |
| HugeNav | 3133 |
| wikipedia | HLA-E |
| HLA-E | |
| gopubmed | HLA-E |
| EVS | HLA-E |
| HEFalMp | HLA-E |
| MyGene2 | HLA-E |
| 23andMe | HLA-E |
| UniProt | P13747 |
| Ensembl | ENSG00000204592 |
| OMIM | 143010 |
| # SNPs | 3 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| rs1059510 | 0 | 30,489,955 | |
| rs1264457 | 0 | 30,490,287 | |
| rs1264459 | 0 | 30,488,143 |
HLA-E is gene for a non-classical HLA antigen, with 2 functional variants. It has been connected to multiple cancer prognoses.
HLA-E*0103X is associated with susceptibility to Pemphigus vulgaris and Behcet's disease. E *0101/*0103X is associated with childhood onset diabetes[PMID 23362868]
HLA-E*0101 was associated with hepatitis C clearance in HIV patients with interaction of rs8099917. [PMID 23811951]
HLA-E O1:01 and HLA-E 01:03 have been connected to psoriasis, dependent on HLA-C.[PMID 24279916]
HLA-E genotype was associated with CMV infection after bone marrow transplant [PMID 23998599].
HLA-E*0103/0103 may be protective in allogeneic hematopoietic stem cell transplant [PMID 23395341].
