LRP5
From SNPedia
| is a | gene |
| is | mentioned by |
| Full name | low density lipoprotein receptor-related protein 5 |
| EntrezGene | 4041 |
| PheGenI | 4041 |
| VariationViewer | 4041 |
| ClinVar | LRP5 |
| GeneCards | LRP5 |
| dbSNP | 4041 |
| Diseases | LRP5 |
| SADR | 4041 |
| HugeNav | 4041 |
| wikipedia | LRP5 |
| LRP5 | |
| gopubmed | LRP5 |
| EVS | LRP5 |
| HEFalMp | LRP5 |
| MyGene2 | LRP5 |
| 23andMe | LRP5 |
| UniProt | O75197 |
| Ensembl | ENSG00000162337 |
| OMIM | 603506 |
| # SNPs | 63 |
SNPs in the low-density lipoprotein receptor-related protein 5 LRP gene has been associated with several conditions, most notably:
[1] LRP5 inhibits expression of TPH1, the rate-limiting biosynthetic enzyme for serotonin in enterochromaffin cells of the duodenum. It has been observed that this decreased serotonin blood level normalizes bone formation and bone mass in LRP5-deficient mice. Futhermore, LRP5 inactivation decreases bone formation in a beta-Catenin-independent manner (Serotonin in Gut is Crucial to Bone Formation).
