Paroxetine

A selective serotonin reuptake inhibitor (SSRI), this drug is used to treat depression and some other psychiatric conditions.

Trade names for paroxetine include Paxil and Seroxat.

The following SNPs may influence a patient's response to this drug:

• rs2032583 and others in the ABCB1 gene predict efficacy
• rs4680, the COMT Val/Met SNP, affects paroxetine antidepressant response
• rs6314, in the HTR2A gene