rs1000113
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | normal |
| (C;T) | 1.5x risk of Crohn's disease | |
| (T;T) | 1.9x risk of Crohn's disease |
| Reference | GRCh38 38.1/141 |
| Chromosome | 5 |
| Position | 150860514 |
| Gene | IRGM |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1000113 |
| dbSNP (classic) | rs1000113 |
| ClinGen | rs1000113 |
| ebi | rs1000113 |
| HLI | rs1000113 |
| Exac | rs1000113 |
| Gnomad | rs1000113 |
| Varsome | rs1000113 |
| LitVar | rs1000113 |
| Map | rs1000113 |
| PheGenI | rs1000113 |
| Biobank | rs1000113 |
| 1000 genomes | rs1000113 |
| hgdp | rs1000113 |
| ensembl | rs1000113 |
| geneview | rs1000113 |
| scholar | rs1000113 |
| rs1000113 | |
| pharmgkb | rs1000113 |
| gwascentral | rs1000113 |
| openSNP | rs1000113 |
| 23andMe | rs1000113 |
| SNPshot | rs1000113 |
| SNPdbe | rs1000113 |
| MSV3d | rs1000113 |
| GWAS Ctlg | rs1000113 |
| GMAF | 0.2121 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs1000113 has been reported in a large study to be associated with Crohn's disease.
The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 1.54 (CI 1.31-1.82), and for homozygotes, 1.92 (CI 0.92-4.00). [PMID 17554300
]
| GWAS | |
|---|---|
| SNP | rs1000113 |
| PubMedID | [PMID 17554300]
|
| Condition | Crohn's disease |
| Gene | IRGM |
| Risk Allele | T |
| pValue | 3.00E-007 |
| OR | 1.54 |
| 95% CI | 1.31-1.82 |
[PMID 18224312] Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.
[PMID 19098858] Polymorphism of the IRGM gene might predispose to fistulizing behavior in Crohn's disease.
[PMID 20106866] Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease.
