rs10045431
| Orientation | plus |
| Stabilized | plus |
| Make rs10045431(A;A) |
| Make rs10045431(A;C) |
| Make rs10045431(C;C) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 5 |
| Position | 159387525 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs10045431 |
| dbSNP (classic) | rs10045431 |
| ClinGen | rs10045431 |
| ebi | rs10045431 |
| HLI | rs10045431 |
| Exac | rs10045431 |
| Gnomad | rs10045431 |
| Varsome | rs10045431 |
| LitVar | rs10045431 |
| Map | rs10045431 |
| PheGenI | rs10045431 |
| Biobank | rs10045431 |
| 1000 genomes | rs10045431 |
| hgdp | rs10045431 |
| ensembl | rs10045431 |
| geneview | rs10045431 |
| scholar | rs10045431 |
| rs10045431 | |
| pharmgkb | rs10045431 |
| gwascentral | rs10045431 |
| openSNP | rs10045431 |
| 23andMe | rs10045431 |
| SNPshot | rs10045431 |
| SNPdbe | rs10045431 |
| MSV3d | rs10045431 |
| GWAS Ctlg | rs10045431 |
| GMAF | 0.1758 |
| Max Magnitude | 0 |
| ? | (A;A) (A;C) (C;C) | 28 |
|---|---|---|
|
| ||
| GWAS | |
|---|---|
| SNP | rs10045431 |
| PubMedID | [PMID 18587394 ]
|
| Condition | Crohn's disease |
| Gene | IL12B |
| Risk Allele | C |
| pValue | 4.00E-013 |
| OR | 1.11 |
| 95% CI | |
| GWAS snp | |
|---|---|
| PMID | [PMID 20570966]
|
| Trait | Crohn's disease |
| Title | Fucosyltransferase 2(FUT2) Non-Secretor Status is associated with Crohn's Disease |
| Risk Allele | |
| P-val | 7E-8 |
| Odds Ratio | 1.45 [1.27-1.64] |
DeCode reports that rs10045431 affects susceptibility to Crohn's disease. [PMID 18587394]
[PMID 17587057] Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis.
[PMID 18438406] Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
[PMID 19068216] Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.
[PMID 19468064] Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.
[PMID 19557189] Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.
[PMID 21304977] An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
[PMID 22194214] Replication study of 10 genes showing evidence for association with multiple sclerosis: validation of TMEM39A, IL12B and CBLB [correction of CLBL] genes
[PMID 33390082] The Polymorphisms of Interleukin-12B Gene and Susceptibility to Inflammatory Bowel Diseases: A Meta-analysis and Trial Sequential Analysis.
