rs1006737
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 1.7 | increased risk of Bipolar disorder |
| (G;G) | 0 |
| Make rs1006737(A;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 12 |
| Position | 2236129 |
| Gene | CACNA1C |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1006737 |
| dbSNP (classic) | rs1006737 |
| ClinGen | rs1006737 |
| ebi | rs1006737 |
| HLI | rs1006737 |
| Exac | rs1006737 |
| Gnomad | rs1006737 |
| Varsome | rs1006737 |
| LitVar | rs1006737 |
| Map | rs1006737 |
| PheGenI | rs1006737 |
| Biobank | rs1006737 |
| 1000 genomes | rs1006737 |
| hgdp | rs1006737 |
| ensembl | rs1006737 |
| geneview | rs1006737 |
| scholar | rs1006737 |
| rs1006737 | |
| pharmgkb | rs1006737 |
| gwascentral | rs1006737 |
| openSNP | rs1006737 |
| 23andMe | rs1006737 |
| SNPshot | rs1006737 |
| SNPdbe | rs1006737 |
| MSV3d | rs1006737 |
| GWAS Ctlg | rs1006737 |
| GMAF | 0.3049 |
| Max Magnitude | 1.7 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
| GWAS snp | |
|---|---|
| PMID | [PMID 18711365 ]
|
| Trait | Bipolar disorder |
| Title | Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder |
| Risk Allele | A |
| P-val | 7E-8 |
| Odds Ratio | 1.18 [NR] |
[PMID 19621016] The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia
[PMID 19781653] Effect of CACNA1C rs1006737 on neural correlates of verbal fluency in healthy individuals
| GWAS snp | |
|---|---|
| PMID | [PMID 20351715]
|
| Trait | Bipolar disorder and major depressive disorder (combined) |
| Title | Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder |
| Risk Allele | A |
| P-val | 3E-8 |
| Odds Ratio | 1.18 [NR] (bipolar) |
[PMID 20638048] Genetic variation in CACNA1C, a gene associated with bipolar disorder, influences brainstem rather than gray matter volume in healthy individuals
[PMID 20636642] Evidence for cis-acting regulation of ANK3 and CACNA1C gene expression
[PMID 20679588] Brain function in carriers of a genome-wide supported bipolar disorder variant
[PMID 20819988] Genetic Variation in CACNA1C Affects Brain Circuitries Related to Mental Illness
[PMID 21042317] Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned
[PMID 21292451] Initial evidence for the role of CACNA1C on subcortical brain morphology in patients with bipolar disorder
[PMID 21676128] The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy males
[PMID 22012475] The Effects of CACNA1C Gene Polymorphism on Spatial Working Memory in Both Healthy Controls and Patients with Schizophrenia or Bipolar Disorder
[PMID 22085483] The association of genetic variation in CACNA1C with structure and function of a frontotemporal system
[PMID 19388002] Phenotypic effects of a bipolar liability gene among individuals with major depressive disorder.
[PMID 19416921] Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry.
[PMID 20098439] CACNA1C (rs1006737) is associated with schizophrenia.
[PMID 20226536] Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort.
[PMID 21078228] Effects of a CACNA1C genotype on attention networks in healthy individuals.
[PMID 21395576] No association between bipolar disorder risk polymorphisms in ANK3 and CACNA1C and common migraine.
[PMID 21767209] ANK3, CACNA1C and ZNF804A gene variants in bipolar disorders and psychosis subphenotype.
[PMID 22665259] The psychiatric vulnerability gene CACNA1C and its sex-specific relationship with personality traits, resilience factors and depressive symptoms in the general population.
[PMID 23404764] Association of rs1006737 in CACNA1C with alterations in prefrontal activation and fronto-hippocampal connectivity
[PMID 23406546] The CACNA1C risk allele selectively impacts on executive function in bipolar type I disorder
[PMID 23437284] CACNA1C Risk Variant and Amygdala Activity in Bipolar Disorder, Schizophrenia and Healthy Controls
| GWAS snp | |
|---|---|
| PMID | [PMID 23453885]
|
| Trait | Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) |
| Title | Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. |
| Risk Allele | |
| P-val | 5E-9 |
| Odds Ratio | 1.07 [1.05-1.10] |
[PMID 23979604] A rare mutation of CACNA1C in a patient with bipolar disorder, and decreased gene expression associated with a bipolar-associated common SNP of CACNA1C in brain
[PMID 24108394] Independent Modulation of Engagement and Connectivity of the Facial Network During Affect Processing by CACNA1C and ANK3 Risk Genes for Bipolar Disorder
[PMID 24262814] CACNA1C, schizophrenia and major depressive disorder in the Han Chinese population
[PMID 24269271] The impact of a CACNA1C gene polymorphism on learning and hippocampal formation in healthy individuals: A diffusion tensor imaging study
[PMID 22005930] Genome-wide association study of Alzheimer's disease with psychotic symptoms.
[PMID 22290120] The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D).
[PMID 22914618] Evidence for the impact of the CACNA1C risk allele rs1006737 on 2-year cognitive functioning in bipolar disorder.
[PMID 23070075] Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample.
[PMID 23437964] Suggestive evidence for association between L-type voltage-gated calcium channel (CACNA1C) gene haplotypes and bipolar disorder in Latinos: a family-based association study.
| GWAS snp | |
|---|---|
| PMID | [PMID 24280982]
|
| Trait | Schizophrenia or bipolar disorder |
| Title | Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia. |
| Risk Allele | |
| P-val | 6E-13 |
| Odds Ratio | NR NR |
[PMID 25124521] Replication of previous genome-wide association studies of psychiatric diseases in a large schizophrenia case-control sample from Spain
| GWAS snp | |
|---|---|
| PMID | [PMID 23974872]
|
| Trait | Schizophrenia |
| Title | Genome-wide association analysis identifies 13 new risk loci for schizophrenia. |
| Risk Allele | A |
| P-val | 5E-12 |
| Odds Ratio | 1.10 [1.08-1.13] |
[PMID 25588813] Evaluating the association between CACNA1C rs1006737 and schizophrenia risk: A meta-analysis
[PMID 24643163] Epistatic interaction of genetic depression risk variants in the human subgenual cingulate cortex during memory encoding
[PMID 25843436] CACNA1C SNP rs1006737 associates with bipolar I disorder independent of the Bcl-2 SNP rs956572 variant and its associated effect on intracellular calcium homeostasis
[PMID 26048451] CACNA1C risk variant is associated with increased amygdala volume
[PMID 26204268] Schizophrenia Related Variants in CACNA1C also Confer Risk of Autism
[PMID 26227746] Genetic analysis of SNPs in CACNA1C and ANK3 gene with schizophrenia: A comprehensive meta-analysis
[PMID 26475575] A common risk variant in CACNA1C supports a sex-dependent effect on longitudinal functioning and functional recovery from episodes of schizophrenia-spectrum but not bipolar disorder
[PMID 26541689] CACNA1C polymorphism and altered phosphorylation of tau in bipolar disorder
[PMID 26756527] The impact of CACNA1C allelic variation on regional gray matter volume in Chinese population.
[PMID 27276213] Functional Characterization of Schizophrenia-Associated Variation in CACNA1C.
[PMID 27790829] The impact of CACNA1C gene, and its epistasis with ZNF804A, on white matter microstructure in health, schizophrenia and bipolar disorder.
[PMID 22614292] The impact of CACNA1C allelic variation on effective connectivity during emotional processing in bipolar disorder. During perception of fearful faces, the presence of the A risk allele was associated with decreased outflow of information from medial frontal gyrus (MFG), which was significantly more marked in patients than in their unaffected relatives and healthy controls.
[PMID 31033230] CACNA1C (rs1006737) may be a susceptibility gene for schizophrenia: An updated meta-analysis.
[PMID 33076578] Genetic Risk of Autism Spectrum Disorder in a Pakistani Population.
