rs10090154

plus

Geno	Mag	Summary
(C;C)	0	normal
(C;T)	2	1.4x increased risk for prostate cancer
(T;T)	2.1	1.4x increased risk for prostate cancer

Reference

GRCh38 38.1/141

Chromosome

8

Position

127519892

is a	snp
is	mentioned by
dbSNP	rs10090154
dbSNP (classic)	rs10090154
ClinGen	rs10090154
ebi	rs10090154
HLI	rs10090154
Exac	rs10090154
Gnomad	rs10090154
Varsome	rs10090154
LitVar	rs10090154
Map	rs10090154
PheGenI	rs10090154
Biobank	rs10090154
1000 genomes	rs10090154
hgdp	rs10090154
ensembl	rs10090154
geneview	rs10090154
scholar	rs10090154
google	rs10090154
pharmgkb	rs10090154
gwascentral	rs10090154
openSNP	rs10090154
23andMe	rs10090154
SNPshot	rs10090154
SNPdbe	rs10090154
MSV3d	rs10090154
GWAS Ctlg	rs10090154

GMAF

0.1295

Max Magnitude

2.1

?

(C;C) (C;T) (T;T)

28

rs10090154 is a SNP in chromosome 8q24 "region 1", associated with increased risk for prostate cancer. The odds ratio for the (T) risk allele were 1.42 (CI: 1.07-1.87, p=0.014), and they were not significantly different between Caucasians and African-Americans in this study of ~500 patients.[PMID 18231127 ]

In follow-up studies looking at disease severity (and not just overall risk), this SNP is reported to account for the risk (from region 1) of advanced prostate cancer.[PMID 18231127 ]

Note that a meta-analysis across 10+ studies, including over 15,000 prostate cancer cases, reported the risk for a different SNP (rs1447295) representing the same region, "region 1", of this chromosome.[PMID 1823127]

[PMID 19857256 ] Association between an 8q24 locus and the risk of colorectal cancer in Japanese

[PMID 19866473 ] Association of 17 prostate cancer susceptibility loci with prostate cancer risk in Chinese men

[PMID 21051319 ] Risk of Urinary Bladder Cancer is Associated with 8q24 Variant rs9642880[T]: Results from the Los Angeles-Shanghai Case-Control Study

OMIM	611100
Desc
Variant
Related	also

[PMID 22549899 ] Genetic polymorphism and prostate cancer aggressiveness: A case-only study of 1,536 GWAS and candidate SNPs in African-Americans and European-Americans

[PMID 17618282 ] A common genetic risk factor for colorectal and prostate cancer.

[PMID 18349290] Association of genetic variants at 8q24 with breast cancer risk.

[PMID 18360876 ] Chromosome 8q24 markers: risk of early-onset and familial prostate cancer.

[PMID 18483343] Multiple independent genetic variants in the 8q24 region are associated with prostate cancer risk.

[PMID 18577746 ] Multiple loci with different cancer specificities within the 8q24 gene desert.

[PMID 18704501 ] Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers.

[PMID 19155440 ] Meta association of colorectal cancer confirms risk alleles at 8q24 and 18q21.

[PMID 19520795 ] Novel single nucleotide polymorphism associations with colorectal cancer on chromosome 8q24 in African and European Americans.

[PMID 19680443 ] Functional enhancers at the gene-poor 8q24 cancer-linked locus.

[PMID 20039378 ] Estimation of genotype relative risks from pedigree data by retrospective likelihoods.

[PMID 20584312 ] 8q24 sequence variants in relation to prostate cancer risk among men of African descent: a case-control study.

[PMID 20690139] Meta-analysis of genome-wide and replication association studies on prostate cancer.

[PMID 22099997] Risk loci on chromosome 8q24 are associated with prostate cancer in northern Chinese men.

GWAS snp
PMID	[PMID 22923026 ]
Trait	Prostate cancer
Title	Evaluating genetic risk for prostate cancer among Japanese and Latinos.
Risk Allele	T
P-val	3E-6
Odds Ratio	1.68 [1.35-2.09]

[PMID 23935004 ] Pleiotropic effects of genetic risk variants for other cancers on colorectal cancer risk: PAGE, GECCO and CCFR consortia

[PMID 23628314] A replication study examining association of rs6983267, rs10090154, and rs1447295 common single nucleotide polymorphisms in 8q24 region with prostate cancer in Siberians.