rs10411210
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | |
| (T;T) | 2.1 | 1.15x increased risk of colorectal cancer |
| Make rs10411210(C;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 19 |
| Position | 33041394 |
| Gene | RHPN2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs10411210 |
| dbSNP (classic) | rs10411210 |
| ClinGen | rs10411210 |
| ebi | rs10411210 |
| HLI | rs10411210 |
| Exac | rs10411210 |
| Gnomad | rs10411210 |
| Varsome | rs10411210 |
| LitVar | rs10411210 |
| Map | rs10411210 |
| PheGenI | rs10411210 |
| Biobank | rs10411210 |
| 1000 genomes | rs10411210 |
| hgdp | rs10411210 |
| ensembl | rs10411210 |
| geneview | rs10411210 |
| scholar | rs10411210 |
| rs10411210 | |
| pharmgkb | rs10411210 |
| gwascentral | rs10411210 |
| openSNP | rs10411210 |
| 23andMe | rs10411210 |
| SNPshot | rs10411210 |
| SNPdbe | rs10411210 |
| MSV3d | rs10411210 |
| GWAS Ctlg | rs10411210 |
| GMAF | 0.213 |
| Max Magnitude | 2.1 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
nature colorectal cancer rs10411210 RHPN2; P = 4.6 times 10-9)
In a replication study of ~1,800 Swedish patients, the rs10411210(T) allele was specifically also shown to be associated with younger age of onset for colorectal cancer.[PMID 20648012
]
| GWAS snp | |
|---|---|
| PMID | [PMID 19011631]
|
| Trait | Colorectal cancer |
| Title | Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer |
| Risk Allele | C |
| P-val | 5E-9 |
| Odds Ratio | 1.15 [1.10-1.20] |
[PMID 21119214] Colorectal Cancer Susceptibility Loci in a Population-Based Study: Associations with Morphological Parameters
[PMID 22363440] cis-Expression QTL Analysis of Established Colorectal Cancer Risk Variants in Colon Tumors and Adjacent Normal Tissue
[PMID 22367214] Characterization of gene-environment interactions for colorectal cancer susceptibility loci
[PMID 19639606] Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.
[PMID 20501757] Low-penetrance susceptibility variants in familial colorectal cancer.
[PMID 21071539] Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations.
[PMID 21314996] Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.
[PMID 22045029] Relationship between 16 susceptibility loci and colorectal cancer phenotype in 3146 patients.
[PMID 22235025] Susceptibility genetic variants associated with early-onset colorectal cancer.
[PMID 23359760] Single-nucleotide polymorphism associations for colorectal cancer in southern chinese population
[PMID 22848671] Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.
[PMID 22999960] Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas.
[PMID 23434150] Are the common genetic variants associated with colorectal cancer risk for DNA mismatch repair gene mutation carriers?
[PMID 24854447] Association analysis of colorectal cancer susceptibility variants with gastric cancer in a Chinese Han population
[PMID 25021488] PWE-010 The Association Of Tgfb Signalling Pathway Gene Polymorphisms With Colorectal Cancer Risk: A Meta-analysis
| GWAS snp | |
|---|---|
| PMID | [PMID 24836286]
|
| Trait | Colorectal cancer |
| Title | Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. |
| Risk Allele | C |
| P-val | 3E-6 |
| Odds Ratio | 1.12 [1.07-1.17] |
