[PMID 19416921
] Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. Published 2009. Found that "The most strongly associated nonsynonymous SNP rs1042779 (OR = 1.19, P = 1.8 × 10−7) is in the ITIH1 gene on chromosome 3, with other strongly associated nonsynonymous SNPs in GNL3, NEK4, and ITIH3." In particular, "Four additional nonsynonymous SNPs in this region had P < 10−5: rs2289247 (Val367Met) and rs11177 Arg27Gln in GNL3 (guanine nucleotide binding like-3), rs1029871 (Pro225Ala) in NEK4, and rs3617 (Gln315Lys) in ITIH3."
[PMID 20081856] Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1.. Published 2010. In reference to the 2009 research article cited [PMID 19416921], "the most significant SNP in that study was nominally significant in the present study (rs1042779; p=0.001).
[PMID 24389398] ITIH Family Genes Confer Risk to Schizophrenia and Major Depressive Disorder in the Han Chinese Population
] Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. Published 2009. Found that "The most strongly associated nonsynonymous SNP rs1042779 (OR = 1.19, P = 1.8 × 10−7) is in the ITIH1 gene on chromosome 3, with other strongly associated nonsynonymous SNPs in GNL3, NEK4, and ITIH3." In particular, "Four additional nonsynonymous SNPs in this region had P < 10−5: rs2289247 (Val367Met) and rs11177 Arg27Gln in GNL3 (guanine nucleotide binding like-3), rs1029871 (Pro225Ala) in NEK4, and rs3617 (Gln315Lys) in ITIH3."
